Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects

Katrine B Hansen; Tina Vilsbøll; Jonatan I Bagger; Jens Juul Holst; Filip K Knop

doi:10.1210/jc.2011-2594

Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects

Katrine B Hansen, Tina Vilsbøll, Jonatan I Bagger, Jens Juul Holst, Filip K Knop

Afdeling for Klinisk Fysiologi og Nuklearmedicin DIA

47 Citationer (Scopus)

Abstract

The insulinotropic effect of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) is impaired in patients with type 2 diabetes. It remains unclear whether this impairment is a primary pathophysiological trait or a consequence of developing diabetes. Therefore, we aimed to investigate the insulinotropic effect of GIP and GLP-1 compared with placebo before and after 12 d of glucose homeostatic dysregulation in healthy subjects.

Originalsprog	Engelsk
Tidsskrift	Journal of Clinical Endocrinology and Metabolism
Vol/bind	97
Udgave nummer	4
Sider (fra-til)	1363-70
Antal sider	8
ISSN	0021-972X
DOI	https://doi.org/10.1210/jc.2011-2594
Status	Udgivet - 2012

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title = "Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects",

abstract = "The insulinotropic effect of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) is impaired in patients with type 2 diabetes. It remains unclear whether this impairment is a primary pathophysiological trait or a consequence of developing diabetes. Therefore, we aimed to investigate the insulinotropic effect of GIP and GLP-1 compared with placebo before and after 12 d of glucose homeostatic dysregulation in healthy subjects.",

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author = "Hansen, \{Katrine B\} and Tina Vilsb{\o}ll and Bagger, \{Jonatan I\} and Holst, \{Jens Juul\} and Knop, \{Filip K\}",

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AU - Hansen, Katrine B

AU - Vilsbøll, Tina

AU - Bagger, Jonatan I

AU - Holst, Jens Juul

AU - Knop, Filip K

PY - 2012

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N2 - The insulinotropic effect of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) is impaired in patients with type 2 diabetes. It remains unclear whether this impairment is a primary pathophysiological trait or a consequence of developing diabetes. Therefore, we aimed to investigate the insulinotropic effect of GIP and GLP-1 compared with placebo before and after 12 d of glucose homeostatic dysregulation in healthy subjects.

AB - The insulinotropic effect of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) is impaired in patients with type 2 diabetes. It remains unclear whether this impairment is a primary pathophysiological trait or a consequence of developing diabetes. Therefore, we aimed to investigate the insulinotropic effect of GIP and GLP-1 compared with placebo before and after 12 d of glucose homeostatic dysregulation in healthy subjects.

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KW - Blood Glucose

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KW - Gastric Inhibitory Polypeptide

KW - Glucagon

KW - Glucagon-Like Peptide 1

KW - Glucose Clamp Technique

KW - Glucose Intolerance

KW - Glucose Tolerance Test

KW - Humans

KW - Incretins

KW - Infusions, Intravenous

KW - Insulin

KW - Insulin Resistance

KW - Insulin-Secreting Cells

KW - Kinetics

KW - Male

KW - Severity of Illness Index

KW - Young Adult

UR - https://www.scopus.com/pages/publications/84859529805

U2 - 10.1210/jc.2011-2594

DO - 10.1210/jc.2011-2594

M3 - Journal article

C2 - 22319034

SN - 0021-972X

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EP - 1370

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 4

ER -

Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects

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