Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects

45 Citationer (Scopus)

Abstract

The insulinotropic effect of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) is impaired in patients with type 2 diabetes. It remains unclear whether this impairment is a primary pathophysiological trait or a consequence of developing diabetes. Therefore, we aimed to investigate the insulinotropic effect of GIP and GLP-1 compared with placebo before and after 12 d of glucose homeostatic dysregulation in healthy subjects.
OriginalsprogEngelsk
TidsskriftJournal of Clinical Endocrinology and Metabolism
Vol/bind97
Udgave nummer4
Sider (fra-til)1363-70
Antal sider8
ISSN0021-972X
DOI
StatusUdgivet - 2012

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