TY - JOUR
T1 - Impaired fasting glucose in combination with silent myocardial ischaemia is associated with poor prognosis in healthy individuals
AU - Intzilakis, T
AU - Mouridsen, Mette Rauhe
AU - Almdal, T P
AU - Haugaard, S B
AU - Sajadieh, A
N1 - © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK.
PY - 2012
Y1 - 2012
N2 - Aim As both impaired fasting glucose and silent myocardial ischaemia are risk factors for cardiovascular disease and death, we hypothesized that these risk factors in combination would identify those subjects at the highest risk of adverse events. Methods Healthy individuals without diabetes (n = 596, 55-75 years) were examined for silent myocardial infarction (≥ 1 mm ST-interval during ≥ 1 min) by ambulant 48-h continuous electrocardiogram monitoring and impaired fasting glucose (fasting plasma glucose 5.6-6.9 mmol/l). Results After 6.3 years, 77 subjects met the endpoint of myocardial infarction and/or death. The prevalence of silent myocardial ischaemia at inclusion was 12.3% in subjects with impaired fasting glucose and 11.7% in subjects with normal fasting glucose, P = 0.69. Subjects with impaired fasting glucose/silent myocardial ischaemia more often met the endpoint (36%) than subjects with impaired fasting glucose/no silent myocardial ischaemia (15%), subjects with normal fasting glucose/silent myocardial ischaemia (12%), and subjects with normal fasting glucose/no silent myocardial ischaemia (10%), respectively, (P
AB - Aim As both impaired fasting glucose and silent myocardial ischaemia are risk factors for cardiovascular disease and death, we hypothesized that these risk factors in combination would identify those subjects at the highest risk of adverse events. Methods Healthy individuals without diabetes (n = 596, 55-75 years) were examined for silent myocardial infarction (≥ 1 mm ST-interval during ≥ 1 min) by ambulant 48-h continuous electrocardiogram monitoring and impaired fasting glucose (fasting plasma glucose 5.6-6.9 mmol/l). Results After 6.3 years, 77 subjects met the endpoint of myocardial infarction and/or death. The prevalence of silent myocardial ischaemia at inclusion was 12.3% in subjects with impaired fasting glucose and 11.7% in subjects with normal fasting glucose, P = 0.69. Subjects with impaired fasting glucose/silent myocardial ischaemia more often met the endpoint (36%) than subjects with impaired fasting glucose/no silent myocardial ischaemia (15%), subjects with normal fasting glucose/silent myocardial ischaemia (12%), and subjects with normal fasting glucose/no silent myocardial ischaemia (10%), respectively, (P
U2 - 10.1111/j.1464-5491.2012.03639.x
DO - 10.1111/j.1464-5491.2012.03639.x
M3 - Journal article
C2 - 22413776
VL - 29
SP - e163–e169
JO - Diabet Med
JF - Diabet Med
SN - 0742-3071
IS - 8
ER -