Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Impaired collagen synthesis in the rectum may be a molecular target in anastomotic leakage prophylaxis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Molecular and histological studies of bladder wound healing in a rodent model

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Non-invasive measurement of reepithelialization and microvascularity of suction-blister wounds with benchmarking to histology

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Consensus guidelines for the identification and treatment of biofilms in chronic nonhealing wounds

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Antiscarring pharmaceuticals: lost in translation?

    Publikation: Bidrag til tidsskriftLederForskningpeer review

Vis graf over relationer

The underlying molecular mechanisms for anastomotic leakage (AL) after colorectal surgery are unknown and there are no therapeutics for AL prevention. Our aim was to correlate endogenous matrix metalloproteinase (MMP) activity, collagen concentration, and collagen/MMP/cytokine mRNA levels with anatomic location in human colorectal tissue. We enrolled 22 patients in this prospective study: 7 underwent elective laparoscopic sigmoid resection and 15 underwent low anterior resection for colorectal cancer. Full-thickness intestinal tissue rings from anastomoses constructed with a circular stapler were used for the determination of the MMP activity, tissue collagen concentration and mRNA levels. COL1A1 (p = 0.017) and COL3A1 (p = 0.0013) mRNA levels were lower in rectal tissue than in colonic samples. Neither MMP activities nor collagen concentrations differed significantly between the two anatomic locations. By elucidating the factors responsible for the decreased collagen production we may identify specific molecular targets in AL prophylaxis.

OriginalsprogEngelsk
TidsskriftWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Vol/bind25
Udgave nummer3
Sider (fra-til)532-535
Antal sider4
ISSN1067-1927
DOI
StatusUdgivet - maj 2017

ID: 52121452