Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Impact of xanthohumol (a prenylated flavonoid from hops) on DNA stability and other health-related biochemical parameters: Results of human intervention trials

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Rational Design, Structure-Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Resveratrol inhibits steroidogenesis in human fetal adrenocortical cells at the end of first trimester

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Dietary exposure to benzoxazinoids enhances bacteria-induced monokine responses by peripheral blood mononuclear cells

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Franziska Ferk
  • Miroslav Mišík
  • Armen Nersesyan
  • Christoph Pichler
  • Walter Jäger
  • Thomas Szekeres
  • Rodrig Marculescu
  • Henrik E Poulsen
  • Trine Henriksen
  • Roberto Bono
  • Valeria Romanazzi
  • Halh Al-Serori
  • Martin Biendl
  • Karl-Heinz Wagner
  • Michael Kundi
  • Siegfried Knasmüller
Vis graf over relationer

SCOPE: Xanthohumol (XN) is a hop flavonoid found in beers and refreshment drinks. Results of in vitro and animal studies indicate that it causes beneficial health effects due to DNA protective, anti-inflammatory, antioxidant, and phytoestrogenic properties. Aim of the present study was to find out if XN causes alterations of health-related parameters in humans.

METHODS AND RESULTS: The effects of the flavonoid were investigated in a randomized crossover intervention trial (n = 22) in which the participants consumed a XN drink (12 mg XN/P/day). We monitored alterations of the DNA stability in single cell gel electrophoresis assays in lymphocytes and of several health-related biomarkers. A decrease of oxidatively damaged purines and protection toward reactive oxygen species induced DNA damage was found after the consumption of the beverage; also the excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-guanosine in urine was reduced. The assumption that the flavonoid causes DNA protection was confirmed in a randomized follow-up study with pure XN (n = 10) with a parallel design. Other biochemical parameters reflecting the redox- and hormonal status and lipid- and glucose metabolism were not altered after the intervention.

CONCLUSION: Taken together, our data indicate that low doses of XN protect humans against oxidative DNA damage.

OriginalsprogEngelsk
TidsskriftMolecular Nutrition & Food Research
Vol/bind60
Udgave nummer4
Sider (fra-til)773-86
Antal sider14
ISSN1613-4125
DOI
StatusUdgivet - apr. 2016

ID: 49512765