Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty

Kaspar Sørensen; Lise Aksglaede; Thor Munch-Andersen; Niels Jacob Aachmann-Andersen; Henrik Leffers; Jørn Wulff Helge; Linda Hilsted; Anders Juul

doi:10.1210/jc.2009-0313

Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty

Kaspar Sørensen
, Lise Aksglaede
, Thor Munch-Andersen
, Niels Jacob Aachmann-Andersen
, Henrik Leffers
, Jørn Wulff Helge
, Linda Hilsted
, Anders Juul

26 Citationer (Scopus)

Abstract

The GH/IGF-I axis has major impact on insulin sensitivity and insulin secretion. Recently a polymorphism in the GH receptor gene (GHR), a genomic deletion of exon 3 (GHRd3), has been linked to increased responsiveness to GH.

Originalsprog	Engelsk
Tidsskrift	Journal of Clinical Endocrinology and Metabolism
Vol/bind	94
Udgave nummer	8
Sider (fra-til)	2966-9
Antal sider	4
ISSN	0021-972X
DOI	https://doi.org/10.1210/jc.2009-0313
Status	Udgivet - 2009
Udgivet eksternt	Ja

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10.1210/jc.2009-0313

Citationsformater

Sørensen, K., Aksglaede, L., Munch-Andersen, T., Aachmann-Andersen, N. J., Leffers, H., Helge, J. W., Hilsted, L., & Juul, A. (2009). Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty. Journal of Clinical Endocrinology and Metabolism, 94(8), 2966-9. https://doi.org/10.1210/jc.2009-0313

Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty. / Sørensen, Kaspar; Aksglaede, Lise; Munch-Andersen, Thor et al.
I: Journal of Clinical Endocrinology and Metabolism, Bind 94, Nr. 8, 2009, s. 2966-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Sørensen, K, Aksglaede, L, Munch-Andersen, T, Aachmann-Andersen, NJ, Leffers, H, Helge, JW, Hilsted, L & Juul, A 2009, 'Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty', Journal of Clinical Endocrinology and Metabolism, bind 94, nr. 8, s. 2966-9. https://doi.org/10.1210/jc.2009-0313

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title = "Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty",

abstract = "The GH/IGF-I axis has major impact on insulin sensitivity and insulin secretion. Recently a polymorphism in the GH receptor gene (GHR), a genomic deletion of exon 3 (GHRd3), has been linked to increased responsiveness to GH.",

keywords = "Adolescent, Alleles, Child, Cross-Sectional Studies, Exons, Female, Gene Deletion, Glucose, Humans, Insulin, Insulin-Like Growth Factor I, Male, Polymorphism, Genetic, Puberty, Receptors, Somatotropin, Triglycerides",

author = "Kaspar S{\o}rensen and Lise Aksglaede and Thor Munch-Andersen and Aachmann-Andersen, \{Niels Jacob\} and Henrik Leffers and Helge, \{J{\o}rn Wulff\} and Linda Hilsted and Anders Juul",

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doi = "10.1210/jc.2009-0313",

language = "English",

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T1 - Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty

AU - Sørensen, Kaspar

AU - Aksglaede, Lise

AU - Munch-Andersen, Thor

AU - Aachmann-Andersen, Niels Jacob

AU - Leffers, Henrik

AU - Helge, Jørn Wulff

AU - Hilsted, Linda

AU - Juul, Anders

PY - 2009

Y1 - 2009

N2 - The GH/IGF-I axis has major impact on insulin sensitivity and insulin secretion. Recently a polymorphism in the GH receptor gene (GHR), a genomic deletion of exon 3 (GHRd3), has been linked to increased responsiveness to GH.

AB - The GH/IGF-I axis has major impact on insulin sensitivity and insulin secretion. Recently a polymorphism in the GH receptor gene (GHR), a genomic deletion of exon 3 (GHRd3), has been linked to increased responsiveness to GH.

KW - Adolescent

KW - Alleles

KW - Child

KW - Cross-Sectional Studies

KW - Exons

KW - Female

KW - Gene Deletion

KW - Glucose

KW - Humans

KW - Insulin

KW - Insulin-Like Growth Factor I

KW - Male

KW - Polymorphism, Genetic

KW - Puberty

KW - Receptors, Somatotropin

KW - Triglycerides

U2 - 10.1210/jc.2009-0313

DO - 10.1210/jc.2009-0313

M3 - Journal article

C2 - 19417039

SN - 0021-972X

VL - 94

SP - 2966

EP - 2969

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 8

ER -

Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty

Abstract

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