Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Impact of schizophrenia and related disorders on mortality from breast cancer: A population-based cohort study in Denmark, 1995-2011

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Development of Sarcopenia in Patients With Bladder Cancer: A Systematic Review

    Publikation: Bidrag til tidsskriftReviewpeer review

  2. Early indicators of primary brain tumours: a population-based study with 10 years’ follow-up

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Gynaecological cancer leads to long-term sick leave and permanently reduced working ability years after diagnosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Patterns in detection of recurrence among patients treated for breast cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVES: To investigate overall and breast cancer-specific mortality in early-stage breast cancer patients with and without schizophrenia or related disorders.

METHODS: We used Danish national registers to identify all women with no prior history of cancer or organic mental disorders, who were diagnosed with early-stage breast cancer 1995-2011. Logistic regression models were used to calculate the odds ratios (ORs) for not being allocated to guideline treatment. Cox regression models were used to compute hazard ratios (HRs) for overall and breast cancer-specific deaths among women allocated or not allocated to guideline treatment.

RESULTS: We identified 56,152 women with early-stage breast cancer diagnosed in 1995-2011, of whom 499 women also had been diagnosed with schizophrenia or related disorders. The likelihood of women with schizophrenia or related disorders for not being allocated to guideline treatment was increased (adjusted OR, 1.50; 95% confidence interval (CI), 1.15-1.94). The adjusted HR for all-cause mortality was 1.55; 95% CI, 1.32-1.82 and 1.12 (95% CI, 0.98-1.50) for breast cancer-specific mortality; women allocated to guideline treatment had an adjusted HR for breast cancer-specific death of 1.42 (95% CI, 1.11-1.82). The adjusted HR for death due to unnatural causes was 3.67 (95% CI, 1.80-7.35).

CONCLUSION: The survival of women with schizophrenia or related disorders after breast cancer is significantly worse than that of women without these disorders. These patients are less likely to be allocated to guideline treatment, and, among those who are, mortality from both breast cancer and other causes is increased.

OriginalsprogEngelsk
TidsskriftBreast
Vol/bind40
Sider (fra-til)170-176
Antal sider7
ISSN0960-9776
DOI
StatusUdgivet - aug. 2018

ID: 54866980