Impact of rs361072 in the phosphoinositide 3-kinase p110beta gene on whole-body glucose metabolism and subunit protein expression in skeletal muscle

Rasmus Ribel-Madsen, Pernille Poulsen, Johan Holmkvist, Brynjulf Mortensen, Niels Grarup, Martin Friedrichsen, Torben Jørgensen, Torsten Lauritzen, Jørgen Wojtaszewski, Oluf Pedersen, Torben Hansen, Allan Vaag

    4 Citationer (Scopus)

    Abstract

    Phosphoinositide 3-kinase (PI3K) is a major effector in insulin signaling. rs361072, located in the promoter of the gene (PIK3CB) for the p110beta subunit, has previously been found to be associated with homeostasis model assessment for insulin resistance (HOMA-IR) in obese subjects. The aim was to investigate the influence of rs361072 on in vivo glucose metabolism, skeletal muscle PI3K subunit protein levels, and type 2 diabetes.
    OriginalsprogEngelsk
    TidsskriftDiabetes
    Vol/bind59
    Udgave nummer4
    Sider (fra-til)1108-12
    Antal sider5
    DOI
    StatusUdgivet - 1 apr. 2010

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