TY - JOUR
T1 - Impact of rs361072 in the phosphoinositide 3-kinase p110beta gene on whole-body glucose metabolism and subunit protein expression in skeletal muscle
AU - Ribel-Madsen, Rasmus
AU - Poulsen, Pernille
AU - Holmkvist, Johan
AU - Mortensen, Brynjulf
AU - Grarup, Niels
AU - Friedrichsen, Martin
AU - Jørgensen, Torben
AU - Lauritzen, Torsten
AU - Wojtaszewski, Jørgen
AU - Pedersen, Oluf
AU - Hansen, Torben
AU - Vaag, Allan
PY - 2010/4/1
Y1 - 2010/4/1
N2 - Phosphoinositide 3-kinase (PI3K) is a major effector in insulin signaling. rs361072, located in the promoter of the gene (PIK3CB) for the p110beta subunit, has previously been found to be associated with homeostasis model assessment for insulin resistance (HOMA-IR) in obese subjects. The aim was to investigate the influence of rs361072 on in vivo glucose metabolism, skeletal muscle PI3K subunit protein levels, and type 2 diabetes.
AB - Phosphoinositide 3-kinase (PI3K) is a major effector in insulin signaling. rs361072, located in the promoter of the gene (PIK3CB) for the p110beta subunit, has previously been found to be associated with homeostasis model assessment for insulin resistance (HOMA-IR) in obese subjects. The aim was to investigate the influence of rs361072 on in vivo glucose metabolism, skeletal muscle PI3K subunit protein levels, and type 2 diabetes.
U2 - 10.2337/db09-1359
DO - 10.2337/db09-1359
M3 - Journal article
C2 - 20107106
VL - 59
SP - 1108
EP - 1112
JO - Diabetes
JF - Diabetes
IS - 4
ER -