TY - JOUR
T1 - Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls
AU - Kring, Sofia Iqbal
AU - Brummett, Beverly H
AU - Barefoot, John
AU - Garrett, Melanie E
AU - Ashley-Koch, Allison E
AU - Boyle, Stephen H
AU - Siegler, Ilene C
AU - Sørensen, Thorkild I A
AU - Williams, Redford B
PY - 2010/6/1
Y1 - 2010/6/1
N2 - To examine the association between apolipoprotein E (APOE) gene variants and waist circumference, fasting plasma glucose, serum insulin, serum high-density lipoprotein cholesterol, and serum triglycerides, all metabolic traits known as cardiovascular disease (CVD) endophenotypes, in a population of stressed individuals and controls. Abdominal obesity, insulin resistance, elevated serum lipid concentration, and APOE polymorphisms have been associated with CVD risk. Current evidence supports the hypothesis that gene-environment interactions modulate serum lipid concentrations.
AB - To examine the association between apolipoprotein E (APOE) gene variants and waist circumference, fasting plasma glucose, serum insulin, serum high-density lipoprotein cholesterol, and serum triglycerides, all metabolic traits known as cardiovascular disease (CVD) endophenotypes, in a population of stressed individuals and controls. Abdominal obesity, insulin resistance, elevated serum lipid concentration, and APOE polymorphisms have been associated with CVD risk. Current evidence supports the hypothesis that gene-environment interactions modulate serum lipid concentrations.
U2 - 10.1097/PSY.0b013e3181de30ad
DO - 10.1097/PSY.0b013e3181de30ad
M3 - Journal article
C2 - 20467002
SN - 0033-3174
VL - 72
SP - 427
EP - 433
JO - Psychosomatic Medicine
JF - Psychosomatic Medicine
IS - 5
ER -