Impact of polymorphism in the β2-receptor gene on the metabolic response to epinephrine after repeated hypoglycemia

Kim Z Rokamp; Flemming Dela; Niels H Secher; Lars Grønlykke; Birger Thorsteinsson; Ulrik Pedersen-Bjergaard

doi:10.2337/db22-0718

Impact of polymorphism in the β2-receptor gene on the metabolic response to epinephrine after repeated hypoglycemia

Kim Z Rokamp^*, Flemming Dela, Niels H Secher, Lars Grønlykke, Birger Thorsteinsson, Ulrik Pedersen-Bjergaard

^*Corresponding author af dette arbejde

Abstrakt

This study investigates the impact of the β2-receptor gene (ADRB2) polymorphism Gly16Arg on the metabolic response to epinephrine before and after repetitive hypoglycemia. Healthy male subjects being homozygous for either Gly16 (GG; n=12) or Arg16 (AA; n=13) participated in the study. Healthy people with the GG genotype have increased metabolic response to epinephrine, compared to the AA genotype, but without difference between genotype groups after repetitive hypoglycemia.

Originalsprog	Engelsk
Tidsskrift	Diabetes
ISSN	0012-1797
DOI	https://doi.org/10.2337/db22-0718
Status	E-pub ahead of print - 13 mar. 2023

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10.2337/db22-0718

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@article{10a83731a27a43c786be398b8b2548b9,

title = "Impact of polymorphism in the β2-receptor gene on the metabolic response to epinephrine after repeated hypoglycemia",

abstract = "This study investigates the impact of the β2-receptor gene (ADRB2) polymorphism Gly16Arg on the metabolic response to epinephrine before and after repetitive hypoglycemia. Healthy male subjects being homozygous for either Gly16 (GG; n=12) or Arg16 (AA; n=13) participated in the study. Healthy people with the GG genotype have increased metabolic response to epinephrine, compared to the AA genotype, but without difference between genotype groups after repetitive hypoglycemia.",

author = "Rokamp, {Kim Z} and Flemming Dela and Secher, {Niels H} and Lars Gr{\o}nlykke and Birger Thorsteinsson and Ulrik Pedersen-Bjergaard",

note = "{\textcopyright} 2023 by the American Diabetes Association.",

year = "2023",

month = mar,

day = "13",

doi = "10.2337/db22-0718",

language = "English",

journal = "Diabetes",

issn = "0012-1797",

publisher = "American Diabetes Association",

}

TY - JOUR

T1 - Impact of polymorphism in the β2-receptor gene on the metabolic response to epinephrine after repeated hypoglycemia

AU - Rokamp, Kim Z

AU - Dela, Flemming

AU - Secher, Niels H

AU - Grønlykke, Lars

AU - Thorsteinsson, Birger

AU - Pedersen-Bjergaard, Ulrik

PY - 2023/3/13

Y1 - 2023/3/13

N2 - This study investigates the impact of the β2-receptor gene (ADRB2) polymorphism Gly16Arg on the metabolic response to epinephrine before and after repetitive hypoglycemia. Healthy male subjects being homozygous for either Gly16 (GG; n=12) or Arg16 (AA; n=13) participated in the study. Healthy people with the GG genotype have increased metabolic response to epinephrine, compared to the AA genotype, but without difference between genotype groups after repetitive hypoglycemia.

AB - This study investigates the impact of the β2-receptor gene (ADRB2) polymorphism Gly16Arg on the metabolic response to epinephrine before and after repetitive hypoglycemia. Healthy male subjects being homozygous for either Gly16 (GG; n=12) or Arg16 (AA; n=13) participated in the study. Healthy people with the GG genotype have increased metabolic response to epinephrine, compared to the AA genotype, but without difference between genotype groups after repetitive hypoglycemia.

U2 - 10.2337/db22-0718

DO - 10.2337/db22-0718

M3 - Journal article

C2 - 36913730

JO - Diabetes

JF - Diabetes

SN - 0012-1797

ER -

Impact of polymorphism in the β2-receptor gene on the metabolic response to epinephrine after repeated hypoglycemia

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