Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Impact of metabolic dysfunction on cognition in humans

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Polygenic risk scores: how much do they add?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Lipoprotein(a): is it more, less or equal to LDL as a causal factor for cardiovascular disease and mortality?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Apolipoprotein M/sphingosine-1-phosphate: novel effects on lipids, inflammation and kidney biology

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Remnant lipoproteins

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Relation between plasma and brain lipids

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Plasma concentrations of magnesium and risk of dementia: a general population study of 102 648 individuals

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. HDL cholesterol and non-cardiovascular disease: a narrative review

    Publikation: Bidrag til tidsskriftReviewpeer review

  3. Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

PURPOSE OF REVIEW: The current review evaluates the recent literature on the impact of metabolic dysfunction in human cognition, focusing on epidemiological studies and meta-analyses of these.

RECENT FINDINGS: Worldwide around 50 million people live with dementia, a number projected to triple by 2050. Recent reports from the Lancet Commission suggest that 40% of dementia cases may be preventable primarily by focusing on well established metabolic dysfunction components and cardiovascular risk factors.

SUMMARY: There is robust evidence that type 2 diabetes and midlife hypertension increase risk of dementia in late life. Obesity and elevated levels of LDL cholesterol in midlife probably increase risk of dementia, but further research is needed in these areas. Physical activity, diet, alcohol, and smoking might also influence the risk of dementia through their effect on metabolic dysfunction. A key recommendation is to be ambitious about prevention, focusing on interventions to promote healthier lifestyles combating metabolic dysfunction. Only comprehensive multidomain and staff-requiring interventions are however efficient to maintain or improve cognition in at-risk individuals and will be unrealistic economic burdens for most societies to implement. Therefore, a risk score that identifies high-risk individuals will enable a targeted early intensive intervention toward those high-risk individuals that will benefit the most from a prevention against cardiovascular risk factors and metabolic dysfunction.

OriginalsprogEngelsk
TidsskriftCurrent Opinion in Lipidology
Vol/bind32
Udgave nummer1
Sider (fra-til)55-61
Antal sider7
ISSN0957-9672
DOI
StatusUdgivet - 1 feb. 2021

Bibliografisk note

Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

ID: 61761237