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Impact of Hiv-Related Gut Microbiota Alterations on Metabolic Comorbidities

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@article{99ccbfdbd8b04db3afb44216d31cdc6a,
title = "Impact of Hiv-Related Gut Microbiota Alterations on Metabolic Comorbidities",
abstract = "BACKGROUND: We aimed to identify an HIV-related microbiota signature, independent of sexual preferences and demographic confounders, in order to assess a possible impact of the microbiome on metabolic comorbidites.METHODS: Bacterial 16S rRNA analyses were performed on stool samples from 405 HIV-infected and 111 uninfected participants of the Copenhagen Comorbidity in HIV infection (COCOMO) study. Individuals were stratified according to sexual behaviour (men who have sex with men, MSM and non-MSM).RESULTS: After excluding MSM-associated microbiota traits and adjusting for confounders, we identified an HIV-related microbiota signature, consisting of lower biodiversity, increased relative abundance of the bacterial clades Gammaproteobacteria and Desulfovibrionaceae and decrease in several Clostridia. This microbiota profile was associated with a 2-fold excess risk of metabolic syndrome, driven by increase in Desulfovibrionaceae and decrease in Clostridia (Butyrivibrio, Coprococcus-2, Lachnospiraceae UCG-001 and CAG-56). This association was accentuated (5-fold excess risk) in individuals with previous severe immunodeficiency, which also modified the association between HIV-related microbiota signature and visceral adipose tissue (VAT) area (p-interaction 0.012). Accordingly, HIV-related microbiota was associated with 30 cm2 larger VAT in individuals with history of severe immunodeficiency, but not in those without.CONCLUSION: The HIV-related microbiota was associated with increased risk of metabolic syndrome and VAT accumulation, particularly in individuals with previous severe immunodeficiency, driven by increased Desulfovibrionaceae and lower abundance of several Clostridia. Our findings suggest a potential interplay between HIV-related microbiota, immune dysfunction and metabolic comorbidities. Interventions targeting the gut microbiome may be warranted to reduce cardiovascular risk, particularly in individuals with previous immunodeficiency.",
author = "Marco Gelpi and Beate Vestad and Hansen, {Simen Hyll} and Kristian Holm and Ninna Drivsholm and Alexandra Goetz and Kirkby, {Nicolai S{\o}ren} and Birgitte Lindegaard and Anne-Mette Lebech and Hedda Hoel and Michelsen, {Annika E} and Thor Ueland and Jan Gerstoft and Jens Lundgren and Hov, {Johannes Roksund} and Nielsen, {Susanne Dam} and Marius Tr{\o}seid",
note = "{\circledC} The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2020",
month = "1",
day = "2",
doi = "10.1093/cid/ciz1235",
language = "English",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "University of Chicago Press",

}

RIS

TY - JOUR

T1 - Impact of Hiv-Related Gut Microbiota Alterations on Metabolic Comorbidities

AU - Gelpi, Marco

AU - Vestad, Beate

AU - Hansen, Simen Hyll

AU - Holm, Kristian

AU - Drivsholm, Ninna

AU - Goetz, Alexandra

AU - Kirkby, Nicolai Søren

AU - Lindegaard, Birgitte

AU - Lebech, Anne-Mette

AU - Hoel, Hedda

AU - Michelsen, Annika E

AU - Ueland, Thor

AU - Gerstoft, Jan

AU - Lundgren, Jens

AU - Hov, Johannes Roksund

AU - Nielsen, Susanne Dam

AU - Trøseid, Marius

N1 - © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2020/1/2

Y1 - 2020/1/2

N2 - BACKGROUND: We aimed to identify an HIV-related microbiota signature, independent of sexual preferences and demographic confounders, in order to assess a possible impact of the microbiome on metabolic comorbidites.METHODS: Bacterial 16S rRNA analyses were performed on stool samples from 405 HIV-infected and 111 uninfected participants of the Copenhagen Comorbidity in HIV infection (COCOMO) study. Individuals were stratified according to sexual behaviour (men who have sex with men, MSM and non-MSM).RESULTS: After excluding MSM-associated microbiota traits and adjusting for confounders, we identified an HIV-related microbiota signature, consisting of lower biodiversity, increased relative abundance of the bacterial clades Gammaproteobacteria and Desulfovibrionaceae and decrease in several Clostridia. This microbiota profile was associated with a 2-fold excess risk of metabolic syndrome, driven by increase in Desulfovibrionaceae and decrease in Clostridia (Butyrivibrio, Coprococcus-2, Lachnospiraceae UCG-001 and CAG-56). This association was accentuated (5-fold excess risk) in individuals with previous severe immunodeficiency, which also modified the association between HIV-related microbiota signature and visceral adipose tissue (VAT) area (p-interaction 0.012). Accordingly, HIV-related microbiota was associated with 30 cm2 larger VAT in individuals with history of severe immunodeficiency, but not in those without.CONCLUSION: The HIV-related microbiota was associated with increased risk of metabolic syndrome and VAT accumulation, particularly in individuals with previous severe immunodeficiency, driven by increased Desulfovibrionaceae and lower abundance of several Clostridia. Our findings suggest a potential interplay between HIV-related microbiota, immune dysfunction and metabolic comorbidities. Interventions targeting the gut microbiome may be warranted to reduce cardiovascular risk, particularly in individuals with previous immunodeficiency.

AB - BACKGROUND: We aimed to identify an HIV-related microbiota signature, independent of sexual preferences and demographic confounders, in order to assess a possible impact of the microbiome on metabolic comorbidites.METHODS: Bacterial 16S rRNA analyses were performed on stool samples from 405 HIV-infected and 111 uninfected participants of the Copenhagen Comorbidity in HIV infection (COCOMO) study. Individuals were stratified according to sexual behaviour (men who have sex with men, MSM and non-MSM).RESULTS: After excluding MSM-associated microbiota traits and adjusting for confounders, we identified an HIV-related microbiota signature, consisting of lower biodiversity, increased relative abundance of the bacterial clades Gammaproteobacteria and Desulfovibrionaceae and decrease in several Clostridia. This microbiota profile was associated with a 2-fold excess risk of metabolic syndrome, driven by increase in Desulfovibrionaceae and decrease in Clostridia (Butyrivibrio, Coprococcus-2, Lachnospiraceae UCG-001 and CAG-56). This association was accentuated (5-fold excess risk) in individuals with previous severe immunodeficiency, which also modified the association between HIV-related microbiota signature and visceral adipose tissue (VAT) area (p-interaction 0.012). Accordingly, HIV-related microbiota was associated with 30 cm2 larger VAT in individuals with history of severe immunodeficiency, but not in those without.CONCLUSION: The HIV-related microbiota was associated with increased risk of metabolic syndrome and VAT accumulation, particularly in individuals with previous severe immunodeficiency, driven by increased Desulfovibrionaceae and lower abundance of several Clostridia. Our findings suggest a potential interplay between HIV-related microbiota, immune dysfunction and metabolic comorbidities. Interventions targeting the gut microbiome may be warranted to reduce cardiovascular risk, particularly in individuals with previous immunodeficiency.

U2 - 10.1093/cid/ciz1235

DO - 10.1093/cid/ciz1235

M3 - Journal article

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

ER -

ID: 58902952