Impact of HIV Type 1 DNA Levels on Spontaneous Disease Progression: A Meta-Analysis

Chrissa G Tsiara, Georgios K Nikolopoulos, Pantelis G Bagos, Cecile Goujard, Terese L Katzenstein, Albert K Minga, Christine Rouzioux, Angelos Hatzakis

    19 Citationer (Scopus)

    Abstract

    Abstract Several studies have reported the prognostic strength of HIV-1 DNA with variable results however. The aims of the current study were to estimate more accurately the ability of HIV-1 DNA to predict progression of HIV-1 disease toward acquired immunodeficiency syndrome (AIDS) or death, and to compare the prognostic information obtained by HIV-1 DNA with that derived from plasma HIV-1 RNA. Eligible articles were identified through a comprehensive search of Medline, ISI Web of Science, Scopus, and Google Scholar. The analysis included univariate and bivariate random-effects models. The univariate meta-analysis of six studies involving 1074 participants showed that HIV-1 DNA was a strong predictive marker of AIDS [relative risk (RR): 3.01, 95% confidence interval (CI): 1.88-4.82] and of all-cause mortality (RR: 3.49, 95% CI: 2.06-5.89). The bivariate model using the crude estimates of primary studies indicated that HIV-1 DNA was a significantly better predictor than HIV-1 RNA of either AIDS alone (ratio of RRs=1.47, 95% CI: 1.05-2.07) or of combined (AIDS or death) progression outcomes (ratio of RRs=1.51, 95% CI: 1.11-2.05). HIV-1 DNA is a strong predictor of HIV-1 disease progression. Moreover, there is some evidence that HIV-1 DNA might have better predictive value than plasma HIV-1 RNA.
    OriginalsprogEngelsk
    TidsskriftAIDS Research and Human Retroviruses
    Vol/bind28
    Udgave nummer4
    Sider (fra-til)366-73
    ISSN0889-2229
    DOI
    StatusUdgivet - apr. 2012

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