Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation

F Baron; M Labopin; D Niederwieser; S Vigouroux; Joep Cornelissen; C Malm; L L Vindelov; D Blaise; J J W M Janssen; E Petersen; G Socié; A Nagler; V Rocha; M Mohty

doi:10.1038/leu.2012.135

Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation

F Baron, M Labopin, D Niederwieser, S Vigouroux, Joep Cornelissen, C Malm, L L Vindelov, D Blaise, J J W M Janssen, E Petersen, G Socié, A Nagler, V Rocha, M Mohty

159 Citationer (Scopus)

Abstract

This report investigated the impact of graft-versus-host disease (GVHD) on transplantation outcomes in 1859 acute myeloid leukemia patients given allogeneic peripheral blood stem cells after reduced-intensity conditioning (RIC allo-SCT). Grade I acute GVHD was associated with a lower risk of relapse (hazards ratio (HR)=0.7, P=0.02) translating into a trend for better overall survival (OS; HR=1.3; P=0.07). Grade II acute GVHD had no net impact on OS, while grade III-IV acute GVHD was associated with a worse OS (HR=0.4, P

Originalsprog	Engelsk
Tidsskrift	Leukemia
Vol/bind	26
Udgave nummer	12
Sider (fra-til)	2462-8
Antal sider	7
ISSN	0887-6924
DOI	https://doi.org/10.1038/leu.2012.135
Status	Udgivet - 2012

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10.1038/leu.2012.135

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Citationsformater

Baron, F., Labopin, M., Niederwieser, D., Vigouroux, S., Cornelissen, J., Malm, C., Vindelov, L. L., Blaise, D., Janssen, J. J. W. M., Petersen, E., Socié, G., Nagler, A., Rocha, V., & Mohty, M. (2012). Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation. Leukemia, 26(12), 2462-8. https://doi.org/10.1038/leu.2012.135

Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation. / Baron, F; Labopin, M; Niederwieser, D et al.
I: Leukemia, Bind 26, Nr. 12, 2012, s. 2462-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Baron, F, Labopin, M, Niederwieser, D, Vigouroux, S, Cornelissen, J, Malm, C, Vindelov, LL, Blaise, D, Janssen, JJWM, Petersen, E, Socié, G, Nagler, A, Rocha, V & Mohty, M 2012, 'Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation', Leukemia, bind 26, nr. 12, s. 2462-8. https://doi.org/10.1038/leu.2012.135

Baron F, Labopin M, Niederwieser D, Vigouroux S, Cornelissen J, Malm C et al. Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation. Leukemia. 2012;26(12):2462-8. doi: 10.1038/leu.2012.135

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