Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Impact of genetic polymorphism in the β₂-receptor gene on risk of severe hypoglycemia in patients with type 1 diabetes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Dynamic changes of reproductive hormones in male minipuberty: Temporal dissociation of Leydig- and Sertoli-cell activity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Severe mental illness and the risk of diabetes complications. A nationwide register-based cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Patients with cirrhosis have elevated bone turnover but normal hepatic production of osteoprotegerin

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Lipoprotein(a) levels at birth and in early childhood: The COMPARE Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Colonic lactulose fermentation has no impact on glucagon-like peptide-1 and peptide-YY secretion in healthy young men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Rating the importance of outcomes from diabetes trials. A survey of patients’ and doctors’ opinions

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Risk factors for fatigue and impaired function eight months after hospital admission with COVID-19

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Glycemic variability assessed by continuous glucose monitoring in hospitalized patients with community-acquired pneumonia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Context and Objective: Severe hypoglycemic events are unevenly distributed in subjects with type 1 diabetes making a genetic influence probable. The adrenergic beta-2-receptor gene (ADRB2) has several common polymorphisms of which the Arg16 allele is associated with receptor down-regulation and reduced agonist-mediated endogenous glucose production. We tested the hypothesis that the Arg16 variant is associated with severe hypoglycaemia.

Method: A cohort of 311 subjects with type 1 diabetes reported severe hypoglycemic events retrospectively in a validated questionnaire. The subjects were characterized by diabetes history, state of hypoglycemia awareness (Clarke, Gold, and Hillerød methods), C-peptide status, hemoglobin A1c (HbA1c), and ADRB2 genotype.

Results: The ADRB2 Gly16Arg genotype distribution was in Hardy-Weinberg equilibrium. There was a difference in rate of severe hypoglycemia between all genotypes (P=0.01). Subjects homozygous for the Arg16 genotype (AA, n=60) had a relative rate of severe hypoglycemia of 2.2 (CI95 1.3-3.6) compared to subjects homozygous for the Gly16 genotype (GG, n=116) (P=0.002). Among subjects with impaired awareness or unawareness (n=175) those with the AA genotype (n=33) had a relative rate of severe hypoglycemia of 3.2 (CI95 1.7-6.0) compared to subjects with the GG genotype (n=58) (P<0.000). Genotype was not associated with state of hypoglycemia awareness per se as assessed by any of three classification methods. The difference was not explained by other risk factors (duration of diabetes, HbA1c, C-peptide).

Conclusions: Genetic polymorphism in the beta-2-receptor gene is associated with risk of severe hypoglycemia in individuals with type 1 diabetes, especially in those with impaired hypoglycemia awareness.

OriginalsprogEngelsk
TidsskriftThe Journal of clinical endocrinology and metabolism
Vol/bind103
Udgave nummer8
Sider (fra-til)2901-2908
ISSN0021-972X
DOI
StatusUdgivet - 2018

ID: 53793170