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Impact of cystic fibrosis on birthweight: a population based study of children in Denmark and Wales

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Harvard

Schlüter, DK, Griffiths, R, Adam, A, Akbari, A, Heaven, ML, Paranjothy, S, Nybo Andersen, A-M, Carr, SB, Pressler, T, Diggle, PJ & Taylor-Robinson, D 2019, 'Impact of cystic fibrosis on birthweight: a population based study of children in Denmark and Wales' Thorax, bind 74, nr. 5, s. 447-454. https://doi.org/10.1136/thoraxjnl-2018-211706

APA

Schlüter, D. K., Griffiths, R., Adam, A., Akbari, A., Heaven, M. L., Paranjothy, S., ... Taylor-Robinson, D. (2019). Impact of cystic fibrosis on birthweight: a population based study of children in Denmark and Wales. Thorax, 74(5), 447-454. https://doi.org/10.1136/thoraxjnl-2018-211706

CBE

Schlüter DK, Griffiths R, Adam A, Akbari A, Heaven ML, Paranjothy S, Nybo Andersen A-M, Carr SB, Pressler T, Diggle PJ, Taylor-Robinson D. 2019. Impact of cystic fibrosis on birthweight: a population based study of children in Denmark and Wales. Thorax. 74(5):447-454. https://doi.org/10.1136/thoraxjnl-2018-211706

MLA

Vancouver

Schlüter DK, Griffiths R, Adam A, Akbari A, Heaven ML, Paranjothy S o.a. Impact of cystic fibrosis on birthweight: a population based study of children in Denmark and Wales. Thorax. 2019 maj;74(5):447-454. https://doi.org/10.1136/thoraxjnl-2018-211706

Author

Schlüter, Daniela K ; Griffiths, Rowena ; Adam, Abdulfatah ; Akbari, Ashley ; Heaven, Martin L ; Paranjothy, Shantini ; Nybo Andersen, Anne-Marie ; Carr, Siobhán B ; Pressler, Tania ; Diggle, Peter J ; Taylor-Robinson, David. / Impact of cystic fibrosis on birthweight : a population based study of children in Denmark and Wales. I: Thorax. 2019 ; Bind 74, Nr. 5. s. 447-454.

Bibtex

@article{6ab5f0b45da2424681486140602542cd,
title = "Impact of cystic fibrosis on birthweight: a population based study of children in Denmark and Wales",
abstract = "BACKGROUND: Poor growth during infancy and childhood is a characteristic feature of cystic fibrosis (CF). However, the impact of CF on intrauterine growth is unclear. We studied the effect of CF on birth weight in Denmark and Wales, and assessed whether any associations are due to differences in gestational age at birth.METHODS: We conducted national registry linkage studies in two countries, using data for 2.2 million singletons born in Denmark (between 1980 and 2010) and Wales (between 1998 and 2015). We used hospital inpatient and outpatient data to identify 852 children with CF. Using causal mediation methods, we estimated the direct and indirect (via gestational age) effect of CF on birth weight after adjustment for sex, parity and socioeconomic background. We tested the robustness of our results by adjusting for additional factors such as maternal smoking during pregnancy in subpopulations where these data were available.RESULTS: Babies with CF were more likely to be born preterm and with low birth weight than babies with no CF (12.7{\%} vs 5{\%} and 9.4{\%} vs 5.8{\%} preterm; 11.9{\%} vs 4.2{\%} and 11{\%} vs 5.4{\%} low birth weight in Denmark and Wales, respectively). Using causal mediation methods, the total effect of CF on birth weight was estimated to be -178.8 g (95{\%} CI -225.43 to -134.47 g) in the Danish population and -210.08 g (95{\%} CI -281.97 to -141.5 g) in the Welsh population. About 40{\%} of this effect of CF on birth weight was mediated through gestational age.CONCLUSIONS: CF significantly impacts on intrauterine growth and leads to lower birth weight in babies with CF, which is only partially explained by shorter gestation.",
keywords = "clinical epidemiology, cystic fibrosis, Cystic Fibrosis/epidemiology, Follow-Up Studies, Humans, Male, Population Surveillance/methods, Gestational Age, Socioeconomic Factors, Incidence, Birth Weight, Denmark/epidemiology, Outpatients, Adult, Female, Registries, Retrospective Studies, Wales/epidemiology, Infant, Newborn",
author = "Schl{\"u}ter, {Daniela K} and Rowena Griffiths and Abdulfatah Adam and Ashley Akbari and Heaven, {Martin L} and Shantini Paranjothy and {Nybo Andersen}, Anne-Marie and Carr, {Siobh{\'a}n B} and Tania Pressler and Diggle, {Peter J} and David Taylor-Robinson",
note = "{\circledC} Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.",
year = "2019",
month = "5",
doi = "10.1136/thoraxjnl-2018-211706",
language = "English",
volume = "74",
pages = "447--454",
journal = "Thorax",
issn = "0040-6376",
publisher = "B M J Group",
number = "5",

}

RIS

TY - JOUR

T1 - Impact of cystic fibrosis on birthweight

T2 - a population based study of children in Denmark and Wales

AU - Schlüter, Daniela K

AU - Griffiths, Rowena

AU - Adam, Abdulfatah

AU - Akbari, Ashley

AU - Heaven, Martin L

AU - Paranjothy, Shantini

AU - Nybo Andersen, Anne-Marie

AU - Carr, Siobhán B

AU - Pressler, Tania

AU - Diggle, Peter J

AU - Taylor-Robinson, David

N1 - © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.

PY - 2019/5

Y1 - 2019/5

N2 - BACKGROUND: Poor growth during infancy and childhood is a characteristic feature of cystic fibrosis (CF). However, the impact of CF on intrauterine growth is unclear. We studied the effect of CF on birth weight in Denmark and Wales, and assessed whether any associations are due to differences in gestational age at birth.METHODS: We conducted national registry linkage studies in two countries, using data for 2.2 million singletons born in Denmark (between 1980 and 2010) and Wales (between 1998 and 2015). We used hospital inpatient and outpatient data to identify 852 children with CF. Using causal mediation methods, we estimated the direct and indirect (via gestational age) effect of CF on birth weight after adjustment for sex, parity and socioeconomic background. We tested the robustness of our results by adjusting for additional factors such as maternal smoking during pregnancy in subpopulations where these data were available.RESULTS: Babies with CF were more likely to be born preterm and with low birth weight than babies with no CF (12.7% vs 5% and 9.4% vs 5.8% preterm; 11.9% vs 4.2% and 11% vs 5.4% low birth weight in Denmark and Wales, respectively). Using causal mediation methods, the total effect of CF on birth weight was estimated to be -178.8 g (95% CI -225.43 to -134.47 g) in the Danish population and -210.08 g (95% CI -281.97 to -141.5 g) in the Welsh population. About 40% of this effect of CF on birth weight was mediated through gestational age.CONCLUSIONS: CF significantly impacts on intrauterine growth and leads to lower birth weight in babies with CF, which is only partially explained by shorter gestation.

AB - BACKGROUND: Poor growth during infancy and childhood is a characteristic feature of cystic fibrosis (CF). However, the impact of CF on intrauterine growth is unclear. We studied the effect of CF on birth weight in Denmark and Wales, and assessed whether any associations are due to differences in gestational age at birth.METHODS: We conducted national registry linkage studies in two countries, using data for 2.2 million singletons born in Denmark (between 1980 and 2010) and Wales (between 1998 and 2015). We used hospital inpatient and outpatient data to identify 852 children with CF. Using causal mediation methods, we estimated the direct and indirect (via gestational age) effect of CF on birth weight after adjustment for sex, parity and socioeconomic background. We tested the robustness of our results by adjusting for additional factors such as maternal smoking during pregnancy in subpopulations where these data were available.RESULTS: Babies with CF were more likely to be born preterm and with low birth weight than babies with no CF (12.7% vs 5% and 9.4% vs 5.8% preterm; 11.9% vs 4.2% and 11% vs 5.4% low birth weight in Denmark and Wales, respectively). Using causal mediation methods, the total effect of CF on birth weight was estimated to be -178.8 g (95% CI -225.43 to -134.47 g) in the Danish population and -210.08 g (95% CI -281.97 to -141.5 g) in the Welsh population. About 40% of this effect of CF on birth weight was mediated through gestational age.CONCLUSIONS: CF significantly impacts on intrauterine growth and leads to lower birth weight in babies with CF, which is only partially explained by shorter gestation.

KW - clinical epidemiology

KW - cystic fibrosis

KW - Cystic Fibrosis/epidemiology

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Population Surveillance/methods

KW - Gestational Age

KW - Socioeconomic Factors

KW - Incidence

KW - Birth Weight

KW - Denmark/epidemiology

KW - Outpatients

KW - Adult

KW - Female

KW - Registries

KW - Retrospective Studies

KW - Wales/epidemiology

KW - Infant, Newborn

U2 - 10.1136/thoraxjnl-2018-211706

DO - 10.1136/thoraxjnl-2018-211706

M3 - Journal article

VL - 74

SP - 447

EP - 454

JO - Thorax

JF - Thorax

SN - 0040-6376

IS - 5

ER -

ID: 56390127