Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Impact of cardiovascular risk factors and genetics on 10-year absolute risk of dementia: risk charts for targeted prevention

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Volunteer first responders for out-of-hospital cardiac arrest at home: the missing link for improved survival?

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  3. Risk of sports-related sudden cardiac death in women

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Monocyte count and soluble markers of monocyte activation in people living with HIV and uninfected controls

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Self-reported and genetically predicted coffee consumption and smoking in dementia: A Mendelian randomization study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. New insights into the genetic etiology of Alzheimer's disease and related dementias

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Plasma high-density lipoprotein cholesterol and risk of dementia: observational and genetic studies

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

AIMS: Dementia is a major global challenge for health and social care in aging populations. A third of all dementia may be preventable due to cardiovascular risk factors. Intensive multi-domain intervention trials targeting primarily cardiovascular risk factors show improved cognitive function in people at risk. Such interventions will, however, be expensive to implement in all individuals at risk and will represent unrealistic economic tasks for most societies. Therefore, a risk score identifying high-risk individuals is warranted.

METHODS AND RESULTS: In 61 664 individuals from two prospective cohorts of the Danish general population, we generated 10-year absolute risk scores for all-cause dementia from cardiovascular risk factors and genetics. In both sexes, 10-year absolute risk of all-cause dementia increased with increasing age, number of apolipoprotein E (APOE) ɛ4 alleles, number of genome-wide association studies (GWAS) risk alleles, and cardiovascular risk factors. The highest 10-year absolute risks of all-cause dementia seen in smoking women with diabetes, low education, APOE ɛ44 genotype, and 22-31 GWAS risk alleles were 6%, 23%, 48%, and 66% in those aged 50-59, 60-69, 70-79, and 80-100, respectively. Corresponding values for men were 5%, 19%, 42%, and 60%, respectively.

CONCLUSION: Ten-year absolute risk of all-cause dementia increased with age, APOE ɛ4 alleles, GWAS risk alleles, diabetes, low education, and smoking in both women and men. Ten-year absolute risk charts for dementia will facilitate identification of high-risk individuals, those who likely will benefit the most from an early intervention against cardiovascular risk factors.

OriginalsprogEngelsk
TidsskriftEuropean Heart Journal
Vol/bind41
Udgave nummer41
Sider (fra-til)4024-4033
Antal sider10
ISSN0195-668X
DOI
StatusUdgivet - 1 nov. 2020

Bibliografisk note

© The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology.

ID: 61261141