Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Impact of age on the association between 24-h ambulatory blood pressure measurements and target organ damage

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Retinal arteriolar wall-to-lumen ratios at 16-17 years in the Copenhagen Child Cohort 2000 Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Obesity remains a major risk factor associated with vascular stiffening in type 2 diabetes

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

  1. Performance of Prognostic Risk Scores in Heart Failure Patients: Do Sex Differences Exist?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Relationship Between Invasive Hemodynamics and Liver Function in Advanced Heart Failure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Effect of simvastatin and ezetimibe on suPAR levels and outcomes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Pathophysiology-based phenotyping in type 2 diabetes: A clinical classification tool

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: The aim of this study was to evaluate the impact of age on the associations between hemodynamic components derived from 24-h ambulatory blood pressure (24-h ABPM) and target organ damage, in apparently healthy, nonmedicated individuals.

METHODS: Twenty-four-hour ABPM and target organ damage (left ventricular mass index, pulse wave velocity, urine albumin : creatinine ratio and carotid atherosclerotic plaques) were evaluated in 1408 individuals. Associations were examined in regression models, stratified for age [middle-aged (41 or 51 years) or elderly (61 or 71 years)], and adjusted for sex, smoking status, and total-cholesterol.

RESULTS: In middle-aged individuals, an increase of 10 mmHg in 24-h SBP was independently associated with an increase of 3.8 (2.7-4.8) g/m in LVMI. The effect was nearly doubled in the elderly subgroup, where the same increase resulted in an increase in LVMI of 6.3 (5.0-7.6) g/m (P for interaction <0.01). An increase of 10 mmHg of 24-h SBP was associated with a 6.7% increase in pulse wave velocity in middle-aged individuals and with an 9.1% increase in elderly individuals (P for interaction <0.01). An independent association between 24-h ABPM and urine albumin : creatinine ratio was only observed in the elderly subgroup. Associations between the presence of atherosclerotic plaques and components from 24-h ABPM except 24-h DBP were not modified by age (all P for interaction >0.26).

CONCLUSION: Age enhances the associations between hemodynamic components obtained from 24-h ABPM and measures of arterial stiffness, microvascular damage, and cardiac structure, but not atherosclerosis.

OriginalsprogEngelsk
TidsskriftJournal of Hypertension
Vol/bind36
Udgave nummer9
Sider (fra-til)1895-1901
Antal sider7
ISSN0263-6352
DOI
StatusUdgivet - sep. 2018

ID: 56934144