Immunterapiens rolle i behandlingen af kolorektalcancer

Adile Orhan; Sara Mørup; Laurids Østergaard Poulsen; Per Pfeiffer; Camilla Qvortrup; Ismail Gögenur

Immunterapiens rolle i behandlingen af kolorektalcancer

Adile Orhan, Sara Mørup, Laurids Østergaard Poulsen, Per Pfeiffer, Camilla Qvortrup, Ismail Gögenur

Afdeling for Kræftbehandling

Abstract

In Denmark, around 4,500 people are diagnosed with colorectal cancer (CRC) annually. This review investigates that while the efficacy of immunotherapy in CRC is still being studied, immunotherapy is currently only indicated in the treatment of mismatch-repair deficient (dMMR) metastatic CRC, which accounts for 10-15% of patients. Recent studies indicate high rates of pathologic response in dMMR CRC treated with pre-operative immunotherapy while large-scale studies on novel immunotherapy combinations are ongoing.

Bidragets oversatte titel	The role of immunotherapy in the treatment of colorectal cancer
Originalsprog	Dansk
Artikelnummer	V06230371
Tidsskrift	Ugeskrift for Laeger
Vol/bind	185
Udgave nummer	51
ISSN	0041-5782
Status	Udgivet - 18 dec. 2023

Emneord

Colonic Neoplasms
Colorectal Neoplasms/diagnosis
Humans
Immunotherapy
Rectal Neoplasms

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https://ugeskriftet.dk/videnskab/immunterapiens-rolle-i-behandlingen-af-kolorektalcancer

Citationsformater

@article{97d6ce9087234e8a903d24ebcac7aff0,

title = "Immunterapiens rolle i behandlingen af kolorektalcancer",

abstract = "In Denmark, around 4,500 people are diagnosed with colorectal cancer (CRC) annually. This review investigates that while the efficacy of immunotherapy in CRC is still being studied, immunotherapy is currently only indicated in the treatment of mismatch-repair deficient (dMMR) metastatic CRC, which accounts for 10-15% of patients. Recent studies indicate high rates of pathologic response in dMMR CRC treated with pre-operative immunotherapy while large-scale studies on novel immunotherapy combinations are ongoing.",

keywords = "Colonic Neoplasms, Colorectal Neoplasms/diagnosis, Humans, Immunotherapy, Rectal Neoplasms",

author = "Adile Orhan and Sara M{\o}rup and Poulsen, {Laurids {\O}stergaard} and Per Pfeiffer and Camilla Qvortrup and Ismail G{\"o}genur",

note = "Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.",

year = "2023",

month = dec,

day = "18",

language = "Dansk",

volume = "185",

journal = "Ugeskrift for Laeger",

issn = "0041-5782",

publisher = "Almindelige Danske Laegeforening",

number = "51",

}

TY - JOUR

T1 - Immunterapiens rolle i behandlingen af kolorektalcancer

AU - Orhan, Adile

AU - Mørup, Sara

AU - Poulsen, Laurids Østergaard

AU - Pfeiffer, Per

AU - Qvortrup, Camilla

AU - Gögenur, Ismail

N1 - Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.

PY - 2023/12/18

Y1 - 2023/12/18

N2 - In Denmark, around 4,500 people are diagnosed with colorectal cancer (CRC) annually. This review investigates that while the efficacy of immunotherapy in CRC is still being studied, immunotherapy is currently only indicated in the treatment of mismatch-repair deficient (dMMR) metastatic CRC, which accounts for 10-15% of patients. Recent studies indicate high rates of pathologic response in dMMR CRC treated with pre-operative immunotherapy while large-scale studies on novel immunotherapy combinations are ongoing.

AB - In Denmark, around 4,500 people are diagnosed with colorectal cancer (CRC) annually. This review investigates that while the efficacy of immunotherapy in CRC is still being studied, immunotherapy is currently only indicated in the treatment of mismatch-repair deficient (dMMR) metastatic CRC, which accounts for 10-15% of patients. Recent studies indicate high rates of pathologic response in dMMR CRC treated with pre-operative immunotherapy while large-scale studies on novel immunotherapy combinations are ongoing.

KW - Colonic Neoplasms

KW - Colorectal Neoplasms/diagnosis

KW - Humans

KW - Immunotherapy

KW - Rectal Neoplasms

M3 - Review

C2 - 38105736

SN - 0041-5782

VL - 185

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 51

M1 - V06230371

ER -

Immunterapiens rolle i behandlingen af kolorektalcancer

Abstract

Emneord

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Citationsformater