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Immunological effects of dimethyl fumarate treatment in blood and CSF of patients with primary progressive MS

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Vis graf over relationer

Dimethyl fumarate is an efficient therapy used widely in patients with relapsing-remitting multiple sclerosis (RRMS). However, lacking effect of treatment has recently been reported in patients with primary progressive MS (PPMS) (Højsgaard Chow et al., 2021). In order to further analyze the immunological treatment response we investigated the systemic and intrathecal immunological effects of dimethyl fumarate (DMF) treatment in 50 patients with PPMS who participated in a 48-week randomized controlled trial with dimethyl fumarate vs placebo. We found substantial systemic immunomodulatory effects of DMF treatment comparable with those observed in patients with RRMS. However, intrathecal effects were limited and restricted to CD4+ T cells presumably resulting in higher concentrations of intrathecal IL-7.

OriginalsprogEngelsk
Artikelnummer577756
TidsskriftJournal of Neuroimmunology
Vol/bind361
Sider (fra-til)577756
ISSN0165-5728
DOI
StatusUdgivet - 15 dec. 2021

Bibliografisk note

Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

ID: 75774642