Abstract
The biological behavior of oligodendrogliomas is somewhat unpredictable. A supplementing prognostic factor is, therefore, desirable. Thirty-two supratentorial pure oligodendrogliomas were studied immunohistochemically by exposing the tumors to a monoclonal antibody towards the p53 protein, and a polyclonal antibody against the epidermal growth factor receptor (EGFR). A mean p53 labeling index (% of tumor cells stained) of 8.6% and a weak EGFR expression in 18 of the oligodendrogliomas were found. Univariate analysis showed no correlation between p53, EGFR expression and prognosis. Multivariate analysis showed that age was a prognostic factor for survival.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Clinical Neuropathology |
| Vol/bind | 18 |
| Udgave nummer | 4 |
| Sider (fra-til) | 176-80 |
| Antal sider | 5 |
| ISSN | 0722-5091 |
| Status | Udgivet - 1999 |
| Udgivet eksternt | Ja |