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Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge

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Bukh, Jens ; Engle, Ronald E ; Faulk, Kristina ; Wang, Richard Y ; Farci, Patrizia ; Alter, Harvey J ; Purcell, Robert H. / Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge. I: Journal of Virology. 2015 ; Bind 89, Nr. 17. s. 9128-32.

Bibtex

@article{4ca16db9781a4dc2aff7dd102d748fae,
title = "Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge",
abstract = "The importance of neutralizing antibodies (NAbs) in protection against hepatitis C virus (HCV) remains controversial. We infused a chimpanzee with H06 immunoglobulin from a genotype 1a HCV-infected patient and challenged with genotype strains efficiently neutralized by H06 in vitro. Genotype 1a NAbs afforded no protection against genotype 4a or 5a. Protection against homologous 1a lasted 18 weeks, but infection emerged when NAb titers waned. However, 6a infection was prevented. The differential in vivo neutralization patterns have implications for HCV vaccine development.",
author = "Jens Bukh and Engle, {Ronald E} and Kristina Faulk and Wang, {Richard Y} and Patrizia Farci and Alter, {Harvey J} and Purcell, {Robert H}",
note = "Copyright {\circledC} 2015, American Society for Microbiology. All Rights Reserved.",
year = "2015",
month = "9",
day = "1",
doi = "10.1128/JVI.01194-15",
language = "English",
volume = "89",
pages = "9128--32",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "17",

}

RIS

TY - JOUR

T1 - Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge

AU - Bukh, Jens

AU - Engle, Ronald E

AU - Faulk, Kristina

AU - Wang, Richard Y

AU - Farci, Patrizia

AU - Alter, Harvey J

AU - Purcell, Robert H

N1 - Copyright © 2015, American Society for Microbiology. All Rights Reserved.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - The importance of neutralizing antibodies (NAbs) in protection against hepatitis C virus (HCV) remains controversial. We infused a chimpanzee with H06 immunoglobulin from a genotype 1a HCV-infected patient and challenged with genotype strains efficiently neutralized by H06 in vitro. Genotype 1a NAbs afforded no protection against genotype 4a or 5a. Protection against homologous 1a lasted 18 weeks, but infection emerged when NAb titers waned. However, 6a infection was prevented. The differential in vivo neutralization patterns have implications for HCV vaccine development.

AB - The importance of neutralizing antibodies (NAbs) in protection against hepatitis C virus (HCV) remains controversial. We infused a chimpanzee with H06 immunoglobulin from a genotype 1a HCV-infected patient and challenged with genotype strains efficiently neutralized by H06 in vitro. Genotype 1a NAbs afforded no protection against genotype 4a or 5a. Protection against homologous 1a lasted 18 weeks, but infection emerged when NAb titers waned. However, 6a infection was prevented. The differential in vivo neutralization patterns have implications for HCV vaccine development.

U2 - 10.1128/JVI.01194-15

DO - 10.1128/JVI.01194-15

M3 - Journal article

VL - 89

SP - 9128

EP - 9132

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 17

ER -

ID: 45567388