Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Dokumenter

DOI

  1. Replicons of a rodent hepatitis C model virus permit selection of highly permissive cells

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. IDENTIFICATION OF PIPERAZINYLBENZENESULFONAMIDES AS NEW INHIBITORS OF CLAUDIN-1 TRAFFICKING AND HEPATITIS C VIRUS ENTRY

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. An alternate conformation of HCV E2 neutralizing face as an additional vaccine target

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Equine pegiviruses cause persistent infection of bone marrow and are not associated with hepatitis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Evolutionary selection of pestivirus variants with altered or no microRNA dependency

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Antibody Responses to Immunization With HCV Envelope Glycoproteins as a Baseline for B cell-Based Vaccine Development

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Jens Bukh
  • Ronald E Engle
  • Kristina Faulk
  • Richard Y Wang
  • Patrizia Farci
  • Harvey J Alter
  • Robert H Purcell
Vis graf over relationer

The importance of neutralizing antibodies (NAbs) in protection against hepatitis C virus (HCV) remains controversial. We infused a chimpanzee with H06 immunoglobulin from a genotype 1a HCV-infected patient and challenged with genotype strains efficiently neutralized by H06 in vitro. Genotype 1a NAbs afforded no protection against genotype 4a or 5a. Protection against homologous 1a lasted 18 weeks, but infection emerged when NAb titers waned. However, 6a infection was prevented. The differential in vivo neutralization patterns have implications for HCV vaccine development.

OriginalsprogEngelsk
TidsskriftJournal of Virology
Vol/bind89
Udgave nummer17
Sider (fra-til)9128-32
Antal sider5
ISSN0022-538X
DOI
StatusUdgivet - 1 sep. 2015

Mest downloadede publikationer

Ingen data tilgængelig

ID: 45567388