Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Immunogenicity and safety of double dosage of pneumococcal vaccines in adult kidney transplant recipients and waiting list patients: A non-blinded, randomized clinical trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Impact analysis of rotavirus vaccination in various geographic regions in Western Europe

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Respiratory syncytial virus and influenza hospitalizations in Danish children 2010-2016

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Self-reported immunity and opinions on vaccination of hospital personnel among paediatric healthcare workers in Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Hearing loss in fabry disease: A 16 year follow-up study of the Danish nationwide cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Pneumococcal prime-boost vaccination is recommended for solid organ transplant recipients, but is not thoroughly tested in this population. Furthermore, a pneumococcal vaccine dose effect has never been investigated, though observed in healthy adults. To assess whether a double dose of 13-valent pneumococcal conjugate vaccine (PCV13) and of 23-valent pneumococcal polysaccharide vaccine (PPV23) increases the immunogenicity of prime-boost vaccination in kidney transplant recipients (KTRs) and patients on the kidney transplant waiting list (WLPs), a phase 3, randomized, non-blinded trial was conducted.

METHODS: KTRs and WLPs were in parallel groups assigned either normal or double dosage of both vaccines 12 weeks apart. A 'protective response' was an average geometric mean concentration ≥ 1 mg/L based on 12 vaccine shared serotype-specific IgG antibodies. Furthermore, number of antibodies with ≥ 2-fold rises and individual serotype-specific antibody concentrations were evaluated. Follow-up was 48 weeks.

RESULTS: Seventy-four KTRs and 65 WLPs were enrolled. In WLPs, double dosage resulted in a significantly higher proportion of participants with a 'protective response' (66.7%), 5 weeks after PPV23, compared to normal dosage (35.5%), p = 0.015. KTRs exhibited no dose effect. After PPV23, all four groups had increased their number of serotypes with ≥ 2-fold rises (p ≤ 0.05 for both WLPs groups; p ≤ 0.01 for both KTRs groups). Vaccines were safe, well tolerated and still immunogenic at week 48.

CONCLUSIONS: Data suggests that double dosage of pneumococcal vaccines used according to the prime-boost strategy might be recommendable for WLPs. Furthermore, our data supports PPV23́s additive effect to PCV13 in KTRs and WLPs. (EudraCT: 2016-004123-23).

OriginalsprogEngelsk
TidsskriftVaccine
Vol/bind40
Udgave nummer28
Sider (fra-til)3884-3892
Antal sider9
ISSN0264-410X
DOI
StatusUdgivet - 21 jun. 2022

Bibliografisk note

Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.

ID: 78381755