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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Immune cells and prognosis in HPV-associated oropharyngeal squamous cell carcinomas: Review of the literature

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  4. MicroRNA-based classifiers for diagnosis of oral cavity squamous cell carcinoma in tissue and plasma

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  2. Outcome in patients with isolated regional recurrence after primary radiotherapy for head and neck cancer

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Vis graf over relationer

Currently, oropharyngeal squamous cell carcinomas (OPSCC) are treated based on the traditional TNM-classification, although this scheme might be inadequate for the subgroup of human papillomavirus (HPV)-associated OPSCCs. It remains debatable whether this subgroup of patients with favorable prognosis should be offered altered treatment. Besides the well-known biomarkers of HPV and p16, new promising immune cells and markers might nuance the prognosis and treatment for patients with HPV+ OPSCC. We systematically reviewed the literature on immunological features of HPV-associated OPSCCs, and report that a high number of cytotoxic T cells (CD8s) and a low number of CD98 positive cells is associated with better outcome, while an increased CD4/CD8 ratio and a high human leukocyte antigen 1 (HLA1) intensity is most likely associated with worse outcome. These findings might contribute to future OPSCC staging and treatment.

OriginalsprogEngelsk
TidsskriftOral Oncology
Vol/bind58
Sider (fra-til)8-13
Antal sider6
ISSN1368-8375
DOI
StatusUdgivet - jul. 2016

ID: 49659640