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Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

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@article{bccc54bf6f944c14bc7461b08e8925f0,
title = "Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology",
abstract = "Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism.",
author = "Antonio Molinaro and {Bel Lassen}, Pierre and Marcus Henricsson and Hao Wu and Solia Adriouch and Eugeni Belda and Rima Chakaroun and Trine Nielsen and Per-Olof Bergh and Christine Rouault and S{\'e}bastien Andr{\'e} and Florian Marquet and Fabrizio Andreelli and Joe-Elie Salem and Karen Assmann and Jean-Philippe Bastard and Sofia Forslund and {Le Chatelier}, Emmanuelle and Gwen Falony and Nicolas Pons and Edi Prifti and Benoit Quinquis and Hugo Roume and Sara Vieira-Silva and Hansen, {Tue H} and Pedersen, {Helle Krogh} and Christian Lewinter and S{\o}nderskov, {Nadja B} and Lars K{\o}ber and Henrik Vestergaard and Torben Hansen and Jean-Daniel Zucker and Pilar Galan and Marc-Emmanuel Dumas and Jeroen Raes and Jean-Michel Oppert and Ivica Letunic and Jens Nielsen and Peer Bork and Ehrlich, {S Dusko} and Michael Stumvoll and Oluf Pedersen and Judith Aron-Wisneswky and Karine Cl{\'e}ment and Fredrik B{\"a}ckhed and {MetaCardis Consortium} and J{\o}rgensen, {Niklas Rye} and G{\o}tze, {Jens Peter}",
year = "2020",
month = nov,
day = "18",
doi = "10.1038/s41467-020-19589-w",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

AU - Molinaro, Antonio

AU - Bel Lassen, Pierre

AU - Henricsson, Marcus

AU - Wu, Hao

AU - Adriouch, Solia

AU - Belda, Eugeni

AU - Chakaroun, Rima

AU - Nielsen, Trine

AU - Bergh, Per-Olof

AU - Rouault, Christine

AU - André, Sébastien

AU - Marquet, Florian

AU - Andreelli, Fabrizio

AU - Salem, Joe-Elie

AU - Assmann, Karen

AU - Bastard, Jean-Philippe

AU - Forslund, Sofia

AU - Le Chatelier, Emmanuelle

AU - Falony, Gwen

AU - Pons, Nicolas

AU - Prifti, Edi

AU - Quinquis, Benoit

AU - Roume, Hugo

AU - Vieira-Silva, Sara

AU - Hansen, Tue H

AU - Pedersen, Helle Krogh

AU - Lewinter, Christian

AU - Sønderskov, Nadja B

AU - Køber, Lars

AU - Vestergaard, Henrik

AU - Hansen, Torben

AU - Zucker, Jean-Daniel

AU - Galan, Pilar

AU - Dumas, Marc-Emmanuel

AU - Raes, Jeroen

AU - Oppert, Jean-Michel

AU - Letunic, Ivica

AU - Nielsen, Jens

AU - Bork, Peer

AU - Ehrlich, S Dusko

AU - Stumvoll, Michael

AU - Pedersen, Oluf

AU - Aron-Wisneswky, Judith

AU - Clément, Karine

AU - Bäckhed, Fredrik

AU - MetaCardis Consortium

A2 - Jørgensen, Niklas Rye

A2 - Gøtze, Jens Peter

PY - 2020/11/18

Y1 - 2020/11/18

N2 - Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism.

AB - Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism.

UR - http://www.scopus.com/inward/record.url?scp=85096290089&partnerID=8YFLogxK

U2 - 10.1038/s41467-020-19589-w

DO - 10.1038/s41467-020-19589-w

M3 - Journal article

C2 - 33208748

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 5881

ER -

ID: 61275912