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Imaging the inflammatory phenotype in migraine

Publikation: Bidrag til tidsskriftReviewpeer review

DOI

  1. Expression of vasopressin and its receptors in migraine-related regions in CNS and the trigeminal system: influence of sex

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Cardiac cephalalgia: a narrative review and ICHD-3 criteria evaluation

    Publikation: Bidrag til tidsskriftReviewpeer review

  3. Debate: Are cluster headache and migraine distinct headache disorders?

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  4. Microvascular decompression in trigeminal neuralgia - a prospective study of 115 patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Debate: Are cluster headache and migraine distinct headache disorders?

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  2. Interest in and exposure to headache disorders among neurology residents in Denmark: A nationwide cross-sectional survey

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Several preclinical and clinical lines of evidence suggest a role of neuroinflammation in migraine. Neuroimaging offers the possibility to investigate and localize neuroinflammation in vivo in patients with migraine, and to characterize specific inflammatory constituents, such as vascular permeability, and macrophage or microglia activity. Despite all imaging data accumulated on neuroinflammation across the past three decades, an overview of the imaging evidence of neuroinflammation in migraine is still missing.We conducted a systematic review in the Pubmed and Embase databases to evaluate existing imaging data on inflammation in migraine, and to identify gaps in the literature. We included 20 studies investigating migraine without aura (N = 4), migraine with aura (N = 8), both migraine with and without aura (N = 3), or hemiplegic migraine (N = 5).In migraine without aura, macrophage activation was not evident. In migraine with aura, imaging evidence suggested microglial and parameningeal inflammatory activity. Increased vascular permeability was mostly found in hemiplegic migraine, and was atypical in migraine with and without aura. Based on the weight of existing and emerging data, we show that most studies have concentrated on demonstrating increased vascular permeability as a marker of neuroinflammation, with tools that may not have been optimal. In the future, novel, more sensitive techniques, as well as imaging tracers delineating specific inflammatory pathways may further bridge the gap between preclinical and clinical findings.

OriginalsprogEngelsk
Artikelnummer60
TidsskriftThe Journal of Headache and Pain Online
Vol/bind23
Udgave nummer1
Sider (fra-til)60
ISSN1129-2377
DOI
StatusUdgivet - 1 jun. 2022

Bibliografisk note

© 2022. The Author(s).

ID: 78364333