IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease

Elisabet Einarsdottir; Lotta L E Koskinen; Emma Dukes; Kati Kainu; Sari Suomela; Maarit Lappalainen; Fabiana Ziberna; Ilma R Korponay-Szabo; Kalle Kurppa; Katri Kaukinen; Róza Adány; Zsuzsa Pocsai; György Széles; Martti Färkkilä; Ulla Turunen; Leena Halme; Paulina Paavola-Sakki; Tarcisio Not; Serena Vatta; Alessandro Ventura; Robert Löfberg; Leif Torkvist; Francesca Bresso; Jonas Halfvarson; Markku Mäki; Kimmo Kontula; Ulpu Saarialho-Kere; Juha Kere; Mauro D'Amato; Päivi Saavalainen

doi:10.1186/1471-2350-10-8

IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease

Elisabet Einarsdottir, Lotta L E Koskinen, Emma Dukes, Kati Kainu, Sari Suomela, Maarit Lappalainen, Fabiana Ziberna, Ilma R Korponay-Szabo, Kalle Kurppa, Katri Kaukinen, Róza Adány, Zsuzsa Pocsai, György Széles, Martti Färkkilä, Ulla Turunen, Leena Halme, Paulina Paavola-Sakki, Tarcisio Not, Serena Vatta, Alessandro VenturaRobert Löfberg, Leif Torkvist, Francesca Bresso, Jonas Halfvarson, Markku Mäki, Kimmo Kontula, Ulpu Saarialho-Kere, Juha Kere, Mauro D'Amato, Päivi Saavalainen

Allergi, Hud- og Kønssygdomme

60 Citationer (Scopus)

Abstract

BACKGROUND: Association of the interleukin-23 receptor (IL23R) with inflammatory bowel disease (IBD) has been confirmed in several populations. IL23R also associates with psoriasis, suggesting that the gene may be an important candidate for many chronic inflammatory diseases.

METHODS: We studied association of single-nucleotide variants in IL23R with IBD in Swedish patients, in both Crohn's disease (CD) and ulcerative colitis (UC) subsets. The same genetic variants were also studied in Finnish patients with psoriasis or celiac disease, and in Hungarian and Italian patients with celiac disease.

RESULTS: Association of IL23R with IBD was replicated in our Swedish patients, and linkage and association of the IL23R region with psoriasis was found in the Finnish population. The IL23R region was also linked to celiac disease in Finnish families, but no association of IL23R variants with celiac disease was found in the Finnish, Hungarian or Italian samples.

CONCLUSION: Our study is the first to demonstrate association of IL23R with CD and UC in Swedish patients with IBD. It is also the first study to report linkage and association of the IL23R region with psoriasis in the Finnish population. Importantly, this is the first report of linkage of the IL23R region to celiac disease, a chronic inflammatory condition in which IL23R has not been previously implicated.

Originalsprog	Engelsk
Tidsskrift	BMC Medical Genetics
Vol/bind	10
Sider (fra-til)	8
DOI	https://doi.org/10.1186/1471-2350-10-8
Status	Udgivet - 28 jan. 2009

Adgang til dokumentet

10.1186/1471-2350-10-8

Citationsformater

Einarsdottir, E., Koskinen, L. L. E., Dukes, E., Kainu, K., Suomela, S., Lappalainen, M., Ziberna, F., Korponay-Szabo, I. R., Kurppa, K., Kaukinen, K., Adány, R., Pocsai, Z., Széles, G., Färkkilä, M., Turunen, U., Halme, L., Paavola-Sakki, P., Not, T., Vatta, S., ... Saavalainen, P. (2009). IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease. BMC Medical Genetics, 10, 8. https://doi.org/10.1186/1471-2350-10-8

Einarsdottir, E, Koskinen, LLE, Dukes, E, Kainu, K, Suomela, S, Lappalainen, M, Ziberna, F, Korponay-Szabo, IR, Kurppa, K, Kaukinen, K, Adány, R, Pocsai, Z, Széles, G, Färkkilä, M, Turunen, U, Halme, L, Paavola-Sakki, P, Not, T, Vatta, S, Ventura, A, Löfberg, R, Torkvist, L, Bresso, F, Halfvarson, J, Mäki, M, Kontula, K, Saarialho-Kere, U, Kere, J, D'Amato, M & Saavalainen, P 2009, 'IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease', BMC Medical Genetics, bind 10, s. 8. https://doi.org/10.1186/1471-2350-10-8

@article{9b45ddffb3ba4301b0ad062adc5ac678,

title = "IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease",

abstract = "BACKGROUND: Association of the interleukin-23 receptor (IL23R) with inflammatory bowel disease (IBD) has been confirmed in several populations. IL23R also associates with psoriasis, suggesting that the gene may be an important candidate for many chronic inflammatory diseases.METHODS: We studied association of single-nucleotide variants in IL23R with IBD in Swedish patients, in both Crohn's disease (CD) and ulcerative colitis (UC) subsets. The same genetic variants were also studied in Finnish patients with psoriasis or celiac disease, and in Hungarian and Italian patients with celiac disease.RESULTS: Association of IL23R with IBD was replicated in our Swedish patients, and linkage and association of the IL23R region with psoriasis was found in the Finnish population. The IL23R region was also linked to celiac disease in Finnish families, but no association of IL23R variants with celiac disease was found in the Finnish, Hungarian or Italian samples.CONCLUSION: Our study is the first to demonstrate association of IL23R with CD and UC in Swedish patients with IBD. It is also the first study to report linkage and association of the IL23R region with psoriasis in the Finnish population. Importantly, this is the first report of linkage of the IL23R region to celiac disease, a chronic inflammatory condition in which IL23R has not been previously implicated.",

keywords = "Case-Control Studies, Celiac Disease/complications, Colitis, Ulcerative/complications, Crohn Disease/complications, Finland, Genetic Markers, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Hungary, Italy, Linkage Disequilibrium, Psoriasis/complications, Receptors, Interleukin/genetics, Sweden",

author = "Elisabet Einarsdottir and Koskinen, {Lotta L E} and Emma Dukes and Kati Kainu and Sari Suomela and Maarit Lappalainen and Fabiana Ziberna and Korponay-Szabo, {Ilma R} and Kalle Kurppa and Katri Kaukinen and R{\'o}za Ad{\'a}ny and Zsuzsa Pocsai and Gy{\"o}rgy Sz{\'e}les and Martti F{\"a}rkkil{\"a} and Ulla Turunen and Leena Halme and Paulina Paavola-Sakki and Tarcisio Not and Serena Vatta and Alessandro Ventura and Robert L{\"o}fberg and Leif Torkvist and Francesca Bresso and Jonas Halfvarson and Markku M{\"a}ki and Kimmo Kontula and Ulpu Saarialho-Kere and Juha Kere and Mauro D'Amato and P{\"a}ivi Saavalainen",

year = "2009",

month = jan,

day = "28",

doi = "10.1186/1471-2350-10-8",

language = "English",

volume = "10",

pages = "8",

journal = "BMC Medical Genetics",

issn = "1471-2350",

publisher = "BioMed Central Ltd",

}

TY - JOUR

T1 - IL23R in the Swedish, Finnish, Hungarian and Italian populations

T2 - association with IBD and psoriasis, and linkage to celiac disease

AU - Einarsdottir, Elisabet

AU - Koskinen, Lotta L E

AU - Dukes, Emma

AU - Kainu, Kati

AU - Suomela, Sari

AU - Lappalainen, Maarit

AU - Ziberna, Fabiana

AU - Korponay-Szabo, Ilma R

AU - Kurppa, Kalle

AU - Kaukinen, Katri

AU - Adány, Róza

AU - Pocsai, Zsuzsa

AU - Széles, György

AU - Färkkilä, Martti

AU - Turunen, Ulla

AU - Halme, Leena

AU - Paavola-Sakki, Paulina

AU - Not, Tarcisio

AU - Vatta, Serena

AU - Ventura, Alessandro

AU - Löfberg, Robert

AU - Torkvist, Leif

AU - Bresso, Francesca

AU - Halfvarson, Jonas

AU - Mäki, Markku

AU - Kontula, Kimmo

AU - Saarialho-Kere, Ulpu

AU - Kere, Juha

AU - D'Amato, Mauro

AU - Saavalainen, Päivi

PY - 2009/1/28

Y1 - 2009/1/28

N2 - BACKGROUND: Association of the interleukin-23 receptor (IL23R) with inflammatory bowel disease (IBD) has been confirmed in several populations. IL23R also associates with psoriasis, suggesting that the gene may be an important candidate for many chronic inflammatory diseases.METHODS: We studied association of single-nucleotide variants in IL23R with IBD in Swedish patients, in both Crohn's disease (CD) and ulcerative colitis (UC) subsets. The same genetic variants were also studied in Finnish patients with psoriasis or celiac disease, and in Hungarian and Italian patients with celiac disease.RESULTS: Association of IL23R with IBD was replicated in our Swedish patients, and linkage and association of the IL23R region with psoriasis was found in the Finnish population. The IL23R region was also linked to celiac disease in Finnish families, but no association of IL23R variants with celiac disease was found in the Finnish, Hungarian or Italian samples.CONCLUSION: Our study is the first to demonstrate association of IL23R with CD and UC in Swedish patients with IBD. It is also the first study to report linkage and association of the IL23R region with psoriasis in the Finnish population. Importantly, this is the first report of linkage of the IL23R region to celiac disease, a chronic inflammatory condition in which IL23R has not been previously implicated.

AB - BACKGROUND: Association of the interleukin-23 receptor (IL23R) with inflammatory bowel disease (IBD) has been confirmed in several populations. IL23R also associates with psoriasis, suggesting that the gene may be an important candidate for many chronic inflammatory diseases.METHODS: We studied association of single-nucleotide variants in IL23R with IBD in Swedish patients, in both Crohn's disease (CD) and ulcerative colitis (UC) subsets. The same genetic variants were also studied in Finnish patients with psoriasis or celiac disease, and in Hungarian and Italian patients with celiac disease.RESULTS: Association of IL23R with IBD was replicated in our Swedish patients, and linkage and association of the IL23R region with psoriasis was found in the Finnish population. The IL23R region was also linked to celiac disease in Finnish families, but no association of IL23R variants with celiac disease was found in the Finnish, Hungarian or Italian samples.CONCLUSION: Our study is the first to demonstrate association of IL23R with CD and UC in Swedish patients with IBD. It is also the first study to report linkage and association of the IL23R region with psoriasis in the Finnish population. Importantly, this is the first report of linkage of the IL23R region to celiac disease, a chronic inflammatory condition in which IL23R has not been previously implicated.

KW - Case-Control Studies

KW - Celiac Disease/complications

KW - Colitis, Ulcerative/complications

KW - Crohn Disease/complications

KW - Finland

KW - Genetic Markers

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Haplotypes

KW - Humans

KW - Hungary

KW - Italy

KW - Linkage Disequilibrium

KW - Psoriasis/complications

KW - Receptors, Interleukin/genetics

KW - Sweden

U2 - 10.1186/1471-2350-10-8

DO - 10.1186/1471-2350-10-8

M3 - Journal article

C2 - 19175939

SN - 1471-2350

VL - 10

SP - 8

JO - BMC Medical Genetics

JF - BMC Medical Genetics

ER -

IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease

Abstract

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