Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

IL-15 and IL-17F are differentially regulated and expressed in mycosis fungoides (MF)

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Generation of transgene-free porcine intermediate type induced pluripotent stem cells

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Identification of SSEA-1 expressing enhanced reprogramming (SEER) cells in porcine embryonic fibroblasts

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. ELMO3: a direct driver of cancer metastasis?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Keeping each other in check: a reciprocal relationship between cytokines and miRNA

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. STAT5-mediated expression of oncogenic miR-155 in cutaneous T-cell lymphoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Patient-reported Outcomes During Treatment in Patients with Moderate-to-severe Psoriasis: A Danish Nationwide Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Skin colonization by circulating neoplastic clones in cutaneous T-cell lymphoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Skin Patterning in Psoriasis by Spatial Interactions between Pathogenic Cytokines

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. High-Throughput Sequencing-Based Investigation of Viruses in Human Cancers by Multienrichment Approach

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Andreas Willerslev-Olsen
  • Ivan V Litvinov
  • Simon M Fredholm
  • David L Petersen
  • Nina A Sibbesen
  • Robert Gniadecki
  • Qian Zhang
  • Charlotte M Bonefeld
  • Mariusz A Wasik
  • Carsten Geisler
  • Youwen Zhou
  • Anders Woetmann
  • Denis Sasseville
  • Thorbjørn Krejsgaard
  • Niels Odum
Vis graf over relationer

Skin lesions from mycosis fungoides (MF) patients display an increased expression of interleukin-15 (IL-15), IL-17F, and other cytokines implicated in inflammation and malignant cell proliferation in cutaneous T-cell lymphoma (CTCL). In the leukemic variant of CTCL, Sézary syndrome (SS), IL-2 and IL-15 trigger activation of the Jak-3/STAT3 pathway and transcription of IL17A gene, whereas it is unknown what causes IL-15 expression, Jak3/STAT3 activation, and production of IL-17F in MF. Here, we studied the expression and regulation of IL-15 and its relation to IL-17F in MF cell lines and skin lesions from 60 MF patients. We show that: (1) the spontaneous IL-15 mRNA expression is resistant to Jak3 and STAT3 inhibitors at concentrations that profoundly inhibit STAT3 activation and IL-17F mRNA expression; (2) anti-IL-15 antibody blocks STAT3 activation induced by exogenous IL-15 in non-malignant MF T cells, whereas the spontaneous STAT3 activation and IL-17F expression in malignant T cells is not inhibited; (3) patients display heterogeneous IL-15/IL-17F mRNA expression patterns in skin lesions; and (4) IL-15 expression (in contrast to IL-17F) is not associated with progressive disease. Taken together, these findings indicate that IL-15 and IL-17F are differentially regulated and expressed in MF. We propose that IL-15 and IL-17F are markers for different inflammatory environments and play distinct roles in the development and progression of MF.

OriginalsprogEngelsk
TidsskriftCell cycle (Georgetown, Tex.)
Vol/bind13
Udgave nummer8
Sider (fra-til)1306-12
Antal sider7
ISSN1538-4101
DOI
StatusUdgivet - 3 mar. 2014

ID: 45055326