IL-6 Inhibitors and TNF Inhibitors: Impact on Exercise-induced Cardiac Adaptations in Patients With Rheumatoid Arthritis

Simon Jønck; Malte Lund Adamsen; Iben E Rasmussen; Anna A Lytzen; Mathilde Løk; Morten Asp Vonsild Lund; Lene Dreyer; Peter G Jørgensen; Niels Vejlstrup; Lars Køber; Robin Christensen; Søren Jacobsen; Bente Klarlund Pedersen; Helga Ellingsgaard; Pil Højgaard; Ronan M G Berg; Regitse Højgaard Christensen

doi:10.1016/j.jacbts.2024.11.010

IL-6 Inhibitors and TNF Inhibitors: Impact on Exercise-induced Cardiac Adaptations in Patients With Rheumatoid Arthritis

Simon Jønck, Malte Lund Adamsen, Iben E Rasmussen, Anna A Lytzen, Mathilde Løk, Morten Asp Vonsild Lund, Lene Dreyer, Peter G Jørgensen, Niels Vejlstrup, Lars Køber, Robin Christensen, Søren Jacobsen, Bente Klarlund Pedersen, Helga Ellingsgaard, Pil Højgaard, Ronan M G Berg, Regitse Højgaard Christensen

1 Citationer (Scopus)

Abstract

Interleukin-6 inhibitors (IL-6i) are commonly used in patients with rheumatoid arthritis to reduce inflammation from chronically increased IL-6. IL-6 levels increase transiently following exercise, exerting numerous positive effects. This study examined if beneficial exercise-induced cardiac adaptations were attenuated in patients with rheumatoid arthritis in concomitant IL-6i treatment compared with tumor necrosis factor inhibitors. Compared with control, we found that the tumor necrosis factor inhibitor-treated group, but not the IL-6i group, had a significant increase in left ventricular mass following 12 weeks of supervised exercise. However, the interaction effect of treatment modalities on exercise-induced cardiac adaptations was insignificant. (Exercise-induced Cardiac Adaptions in Rheumatoid Arthritis Patients During IL-6 vs TNF Antibody Therapy; NCT05215509).

Originalsprog	Engelsk
Tidsskrift	JACC. Basic to translational science
Vol/bind	10
Udgave nummer	5
Sider (fra-til)	551-563
Antal sider	13
ISSN	2452-302X
DOI	https://doi.org/10.1016/j.jacbts.2024.11.010
Status	Udgivet - maj 2025

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10.1016/j.jacbts.2024.11.010Licens: CC BY-NC-ND

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Jønck, S., Adamsen, M. L., Rasmussen, I. E., Lytzen, A. A., Løk, M., Vonsild Lund, M. A., Dreyer, L., Jørgensen, P. G., Vejlstrup, N., Køber, L., Christensen, R., Jacobsen, S., Pedersen, B. K., Ellingsgaard, H., Højgaard, P., Berg, R. M. G., & Christensen, R. H. (2025). IL-6 Inhibitors and TNF Inhibitors: Impact on Exercise-induced Cardiac Adaptations in Patients With Rheumatoid Arthritis. JACC. Basic to translational science, 10(5), 551-563. https://doi.org/10.1016/j.jacbts.2024.11.010

Jønck, S , Adamsen, ML , Rasmussen, IE , Lytzen, AA , Løk, M , Vonsild Lund, MA, Dreyer, L, Jørgensen, PG , Vejlstrup, N , Køber, L , Christensen, R , Jacobsen, S , Pedersen, BK , Ellingsgaard, H , Højgaard, P , Berg, RMG & Christensen, RH 2025, 'IL-6 Inhibitors and TNF Inhibitors: Impact on Exercise-induced Cardiac Adaptations in Patients With Rheumatoid Arthritis', JACC. Basic to translational science, bind 10, nr. 5, s. 551-563. https://doi.org/10.1016/j.jacbts.2024.11.010

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title = "IL-6 Inhibitors and TNF Inhibitors: Impact on Exercise-induced Cardiac Adaptations in Patients With Rheumatoid Arthritis",

abstract = "Interleukin-6 inhibitors (IL-6i) are commonly used in patients with rheumatoid arthritis to reduce inflammation from chronically increased IL-6. IL-6 levels increase transiently following exercise, exerting numerous positive effects. This study examined if beneficial exercise-induced cardiac adaptations were attenuated in patients with rheumatoid arthritis in concomitant IL-6i treatment compared with tumor necrosis factor inhibitors. Compared with control, we found that the tumor necrosis factor inhibitor-treated group, but not the IL-6i group, had a significant increase in left ventricular mass following 12 weeks of supervised exercise. However, the interaction effect of treatment modalities on exercise-induced cardiac adaptations was insignificant. (Exercise-induced Cardiac Adaptions in Rheumatoid Arthritis Patients During IL-6 vs TNF Antibody Therapy; NCT05215509).",

author = "Simon J{\o}nck and Adamsen, {Malte Lund} and Rasmussen, {Iben E} and Lytzen, {Anna A} and Mathilde L{\o}k and {Vonsild Lund}, {Morten Asp} and Lene Dreyer and J{\o}rgensen, {Peter G} and Niels Vejlstrup and Lars K{\o}ber and Robin Christensen and S{\o}ren Jacobsen and Pedersen, {Bente Klarlund} and Helga Ellingsgaard and Pil H{\o}jgaard and Berg, {Ronan M G} and Christensen, {Regitse H{\o}jgaard}",

year = "2025",

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doi = "10.1016/j.jacbts.2024.11.010",

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AU - Jønck, Simon

AU - Adamsen, Malte Lund

AU - Rasmussen, Iben E

AU - Lytzen, Anna A

AU - Løk, Mathilde

AU - Vonsild Lund, Morten Asp

AU - Dreyer, Lene

AU - Jørgensen, Peter G

AU - Vejlstrup, Niels

AU - Køber, Lars

AU - Christensen, Robin

AU - Jacobsen, Søren

AU - Pedersen, Bente Klarlund

AU - Ellingsgaard, Helga

AU - Højgaard, Pil

AU - Berg, Ronan M G

AU - Christensen, Regitse Højgaard

PY - 2025/5

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N2 - Interleukin-6 inhibitors (IL-6i) are commonly used in patients with rheumatoid arthritis to reduce inflammation from chronically increased IL-6. IL-6 levels increase transiently following exercise, exerting numerous positive effects. This study examined if beneficial exercise-induced cardiac adaptations were attenuated in patients with rheumatoid arthritis in concomitant IL-6i treatment compared with tumor necrosis factor inhibitors. Compared with control, we found that the tumor necrosis factor inhibitor-treated group, but not the IL-6i group, had a significant increase in left ventricular mass following 12 weeks of supervised exercise. However, the interaction effect of treatment modalities on exercise-induced cardiac adaptations was insignificant. (Exercise-induced Cardiac Adaptions in Rheumatoid Arthritis Patients During IL-6 vs TNF Antibody Therapy; NCT05215509).

AB - Interleukin-6 inhibitors (IL-6i) are commonly used in patients with rheumatoid arthritis to reduce inflammation from chronically increased IL-6. IL-6 levels increase transiently following exercise, exerting numerous positive effects. This study examined if beneficial exercise-induced cardiac adaptations were attenuated in patients with rheumatoid arthritis in concomitant IL-6i treatment compared with tumor necrosis factor inhibitors. Compared with control, we found that the tumor necrosis factor inhibitor-treated group, but not the IL-6i group, had a significant increase in left ventricular mass following 12 weeks of supervised exercise. However, the interaction effect of treatment modalities on exercise-induced cardiac adaptations was insignificant. (Exercise-induced Cardiac Adaptions in Rheumatoid Arthritis Patients During IL-6 vs TNF Antibody Therapy; NCT05215509).

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SN - 2452-302X

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IL-6 Inhibitors and TNF Inhibitors: Impact on Exercise-induced Cardiac Adaptations in Patients With Rheumatoid Arthritis

Abstract

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