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Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication

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Vis graf over relationer

Altered coagulation has been reported in people living with HIV (PLWH) with ongoing viral replication and may predispose to cardiovascular diseases. However, less is known about coagulation in PLWH with undetectable viral replication. In a cross-sectional observational study, we investigated whether HIV infection with undetectable viral replication is independently associated with activated partial thromboplastin time (APTT) and coagulation factor II-VII-X concentrations out of reference. Logistic regression analyses were used to assess the association of HIV infection with APTT and coagulation factor II-VII-X, after adjusting for age, sex, smoking status, alcohol consumption, BMI, diabetes and hsCRP. 936 PLWH with undetectable viral replication from the Copenhagen Co-morbidity in HIV infection study (COCOMO-study) and 2955 uninfected controls were included. Higher prevalence of short APTT was found in PLWH compared to controls (13.5% vs. 7.6%, P < 0.001). Furthermore, higher prevalence of low coagulation factor II-VII-X was found in PLWH than in controls (9.6% vs. 7.4%, P = 0.022). HIV was independently associated with short APTT (adjusted odds ratio (aOR) 2.3 (95% CI 1.7-2.9), P < 0.001) and low coagulation factor II-VII-X (aOR 1.4 (95% CI 1.0-1.9), P = 0.046). Few participants among PLWH and controls had both short APTT and low coagulation factor II-VII-X, 2.1% vs. 0.8%, respectively. We found evidence of both procoagulant (short APTT) and anticoagulant (low coagulation factor II-VII-X) alterations in PLWH with undetectable viral replication, and our findings suggest that two different coagulation phenotypes exist in participants with treated HIV infection.

OriginalsprogEngelsk
Artikelnummer4383
TidsskriftScientific Reports
Vol/bind11
Udgave nummer1
Sider (fra-til)4383
ISSN2045-2322
DOI
StatusUdgivet - 23 feb. 2021

Bibliografisk note

Funding Information:
ADK has received research grants from The Danish Heart Foundation and travelling grants from Gilead. RFT has received grants from Rigshospitalets Research Council, Aase og Ejnar Danielsens Fond, Christian den IX og Dronning Louises Jubilæumslegat and travelling grants from Gilead. DMKK has received grants from Simonsen Foundation, Rigshospitalets Research Council and travelling grants from Gilead. SDN has received unrestricted research grants from Novo Nordisk Foundation, Lundbeck Foundation, Augustinus Foundation, Rigshospitalet Research Council. Travelling grants from Gilead and GSK/ViiV. Advisory board activity for Gilead and GSK/ ViiV. For the remaining authors none were declared.

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