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Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Withdrawal: Identification of tumor antigens among the HLA peptidomes of glioblastoma tumors and plasma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Proteomic analysis of Phytophthora infestans reveals the importance of cell wall proteins in pathogenicity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Withdrawal: Identification of tumor antigens among the HLA peptidomes of glioblastoma tumors and plasma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Collagen density regulates the activity of tumor-infiltrating T cells

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Actively personalized vaccination trial for newly diagnosed glioblastoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Extracranial metastases in glioblastoma-Two case stories

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Bracha Shraibman
  • Eilon Barnea
  • Dganit Melamed Kadosh
  • Yael Haimovich
  • Gleb Slobodin
  • Itzhak Rosner
  • Carlos López-Larrea
  • Norbert Hilf
  • Sabrina Kuttruff
  • Colette Song
  • Cedrik Britten
  • John Castle
  • Sebastian Kreiter
  • Katrin Frenzel
  • Marcos Tatagiba
  • Ghazaleh Tabatabai
  • Pierre-Yves Dietrich
  • Valérie Dutoit
  • Wolfgang Wick
  • Michael Platten
  • Frank Winkler
  • Andreas von Deimling
  • Judith Kroep
  • Juan Sahuquillo
  • Francisco Martinez-Ricarte
  • Jordi Rodon
  • Ulrik Lassen
  • Christian Ottensmeier
  • Sjoerd H van der Burg
  • Per Thor Straten
  • Hans Skovgaard Poulsen
  • Berta Ponsati
  • Hideho Okada
  • Hans-Georg Rammensee
  • Ugur Sahin
  • Harpreet Singh
  • Arie Admon
Vis graf over relationer

Glioblastoma multiforme (GBM) is the most aggressive brain tumor with poor prognosis to most patients. Immunotherapy of GBM is a potentially beneficial treatment option, whose optimal implementation may depend on familiarity with tumor specific antigens, presented as HLA peptides by the GBM cells. Further, early detection of GBM, such as by a routine blood test, may improve survival, even with the current treatment modalities. This study includes large-scale analyses of the HLA peptidome (immunopeptidome) of the plasma-soluble HLA molecules (sHLA) of 142 plasma samples, and the membranal HLA of GBM tumors of 10 of these patients' tumor samples. Tumor samples were fresh-frozen immediately after surgery and the plasma samples were collected before, and at multiple visits after surgery. In total, this HLA peptidome analysis involved 52 different HLA allotypes and resulted in the identification of more than 35,000 different HLA peptides. Strong correlations were observed in the signal intensities and in the repertoires of identified peptides between the tumors and plasma-soluble HLA peptidomes of the individual patients, whereas low correlations were observed between these HLA peptidomes and the tumors' proteomes. HLA peptides derived from Cancer/Testis Antigens (CTAs) were selected based on their presence among the HLA peptidomes of the patients and absence of expression of their source genes from any healthy and essential human tissues, except from immune-privileged sites. Additionally, peptides were selected as potential biomarkers if their levels in the plasma-sHLA peptidome were significantly reduced after the removal of tumor mass. The CTAs identified among the analyzed HLA peptidomes provide new opportunities for personalized immunotherapy and for early diagnosis of GBM.

OriginalsprogEngelsk
TidsskriftMolecular & cellular proteomics : MCP
Vol/bind18
Udgave nummer6
Sider (fra-til)1255-1268
Antal sider14
ISSN1535-9476
DOI
StatusUdgivet - jun. 2019

Bibliografisk note

© 2019 Shraibman et al.

ID: 57730986