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Identification of pigments related to allergic tattoo reactions in 104 human skin biopsies

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BACKGROUND: Red tattoos are prone to allergic reactions. The identity of the allergen(s) is mostly unknown.

OBJECTIVES: Chemical analysis of human skin biopsies from chronic allergic reactions in red tattoos to identify culprit pigment(s) and metals.

MATERIAL AND METHODS: One hundred four dermatome biopsies were analyzed by matrix-assisted laser desorption/ionization tandem mass spectrometry (MALDI-MS/MS) for identification of commonly used organic pigments. Metal concentrations were assessed by inductively coupled plasma (ICP)-MS and x-ray fluorescence (XRF). Fourteen patients had cross-reactions in other red tattoos.

RESULTS: In total, the identified pigments were mainly azo Pigment Red (P.R.) 22 (35%), P.R. 210 (24%), P.R. 170 (12%), P.R. 5 (0.9%), P.R. 112 (0.9%), and Pigment Orange (P.O.) 13 (11%). P.R. 122 (0.9%) and Pigment Violet (P.V.) 23 (8%) were also common. P.R. 22, P.R. 170, and P.R. 210 also dominated in patients with cross-reactions. In 22% of the biopsies, no red pigment was detected. Element analysis indicated the presence of the sensitizers nickel and chromium.

CONCLUSIONS: P.R. 22, P.R. 170, and P.R. 210 were identified as the prevailing pigments behind chronic allergic reactions in red tattoos. The epitope causing the reaction might be a pigment-degradation product. Metal contamination may derive from different sources, and its role in red tattoo allergy cannot be ascertained.

OriginalsprogEngelsk
TidsskriftContact Dermatitis
Vol/bind82
Udgave nummer2
Sider (fra-til)73-82
Antal sider10
ISSN0105-1873
DOI
StatusUdgivet - feb. 2020

Bibliografisk note

© 2019 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.

ID: 59384439