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Region Hovedstaden - en del af Københavns Universitetshospital
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Identification of myocardial diffuse fibrosis by 11 heartbeat MOLLI T 1 mapping: averaging to improve precision and correlation with collagen volume fraction

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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  • Vassilios S Vassiliou
  • Katharina Wassilew
  • Donnie Cameron
  • Ee Ling Heng
  • Evangelia Nyktari
  • George Asimakopoulos
  • Anthony de Souza
  • Shivraman Giri
  • Iain Pierce
  • Andrew Jabbour
  • David Firmin
  • Michael Frenneaux
  • Peter Gatehouse
  • Dudley J Pennell
  • Sanjay K Prasad
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OBJECTIVES: Our objectives involved identifying whether repeated averaging in basal and mid left ventricular myocardial levels improves precision and correlation with collagen volume fraction for 11 heartbeat MOLLI T 1 mapping versus assessment at a single ventricular level.

MATERIALS AND METHODS: For assessment of T 1 mapping precision, a cohort of 15 healthy volunteers underwent two CMR scans on separate days using an 11 heartbeat MOLLI with a 5(3)3 beat scheme to measure native T 1 and a 4(1)3(1)2 beat post-contrast scheme to measure post-contrast T 1, allowing calculation of partition coefficient and ECV. To assess correlation of T 1 mapping with collagen volume fraction, a separate cohort of ten aortic stenosis patients scheduled to undergo surgery underwent one CMR scan with this 11 heartbeat MOLLI scheme, followed by intraoperative tru-cut myocardial biopsy. Six models of myocardial diffuse fibrosis assessment were established with incremental inclusion of imaging by averaging of the basal and mid-myocardial left ventricular levels, and each model was assessed for precision and correlation with collagen volume fraction.

RESULTS: A model using 11 heart beat MOLLI imaging of two basal and two mid ventricular level averaged T 1 maps provided improved precision (Intraclass correlation 0.93 vs 0.84) and correlation with histology (R (2) = 0.83 vs 0.36) for diffuse fibrosis compared to a single mid-ventricular level alone. ECV was more precise and correlated better than native T 1 mapping.

CONCLUSION: T 1 mapping sequences with repeated averaging could be considered for applications of 11 heartbeat MOLLI, especially when small changes in native T 1/ECV might affect clinical management.

OriginalsprogEngelsk
TidsskriftMagnetic Resonance Materials in Physics, Biology and Medicine
Vol/bind31
Udgave nummer1
Sider (fra-til)101-113
ISSN0968-5243
DOI
StatusUdgivet - 12 jun. 2017

ID: 51974731