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Identification of alternatively spliced TIMP-1 mRNA in cancer cell lines and colon cancer tissue

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  • P. A. Usher
  • A. M. Sieuwerts
  • A. Bartels
  • U. Lademann
  • Hans Jørgen Nielsen
  • L. Holten-Andersen
  • J. A. Foekens
  • Nils Brünner
  • H. Offenberg
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TIMP-1 is a promising new candidate as a prognostic marker in colorectal and breast cancer. We now describe the discovery of two alternatively spliced variants of TIMP-1 mRNA. The two variants lacking exon 2 (del-2) and 5 (del-5), respectively, were identified in human cancer cell lines by RT-PCR. The del-2 variant was, furthermore, detected in extracts from 12 colorectal cancer tissue samples. By western blotting additional bands of lower molecular mass than full-length TIMP-1 were identified in tumor tissue, but not in plasma samples obtained from cancer patients.

The two splice variants of TIMP-1 may hold important clinical information, and either alone or in combination with measurement of full-length TIMP-1 they may improve the prognostic and/or predictive value of TIMP-1 analyses.


Udgivelsesdato: september
OriginalsprogEngelsk
TidsskriftMolecular Oncology
Vol/bind1
Udgave nummer2
Sider (fra-til)205-15
Antal sider11
DOI
StatusUdgivet - 2007

ID: 32536356