Identification of a pegivirus (GB virus-like virus) that infects horses

Amit Kapoor; Peter Simmonds; John M Cullen; Troels K H Scheel; Jan L Medina; Federico Giannitti; Eiko Nishiuchi; Kenny V Brock; Peter D Burbelo; Charles M Rice; W Ian Lipkin

doi:10.1128/JVI.00324-13

Identification of a pegivirus (GB virus-like virus) that infects horses

Amit Kapoor, Peter Simmonds, John M Cullen, Troels K H Scheel, Jan L Medina, Federico Giannitti, Eiko Nishiuchi, Kenny V Brock, Peter D Burbelo, Charles M Rice, W Ian Lipkin

81 Citationer (Scopus)

Abstract

The recent identification of nonprimate hepaciviruses in dogs and then in horses prompted us to look for pegiviruses (GB virus-like viruses) in these species. Although none were detected in canines, we found widespread natural infection of horses by a novel pegivirus. Unique genomic features and phylogenetic analyses confirmed that the tentatively named equine pegivirus (EPgV) represents a novel species within the Pegivirus genus. We also determined that EPgV causes persistent viremia whereas its clinical significance is undetermined.

Originalsprog	Engelsk
Tidsskrift	Journal of Virology
Vol/bind	87
Udgave nummer	12
Sider (fra-til)	7185-90
Antal sider	6
ISSN	0022-538X
DOI	https://doi.org/10.1128/JVI.00324-13
Status	Udgivet - jun. 2013

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10.1128/JVI.00324-13

Citationsformater

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title = "Identification of a pegivirus (GB virus-like virus) that infects horses",

abstract = "The recent identification of nonprimate hepaciviruses in dogs and then in horses prompted us to look for pegiviruses (GB virus-like viruses) in these species. Although none were detected in canines, we found widespread natural infection of horses by a novel pegivirus. Unique genomic features and phylogenetic analyses confirmed that the tentatively named equine pegivirus (EPgV) represents a novel species within the Pegivirus genus. We also determined that EPgV causes persistent viremia whereas its clinical significance is undetermined.",

keywords = "Amino Acid Sequence, Animals, Base Sequence, Flaviviridae, Flaviviridae Infections, Horse Diseases, Horses, Molecular Sequence Data, Phylogeny, Prevalence, Sequence Analysis, DNA, Species Specificity, United States, Viremia",

author = "Amit Kapoor and Peter Simmonds and Cullen, {John M} and Scheel, {Troels K H} and Medina, {Jan L} and Federico Giannitti and Eiko Nishiuchi and Brock, {Kenny V} and Burbelo, {Peter D} and Rice, {Charles M} and Lipkin, {W Ian}",

year = "2013",

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doi = "10.1128/JVI.00324-13",

language = "English",

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T1 - Identification of a pegivirus (GB virus-like virus) that infects horses

AU - Kapoor, Amit

AU - Simmonds, Peter

AU - Cullen, John M

AU - Scheel, Troels K H

AU - Medina, Jan L

AU - Giannitti, Federico

AU - Nishiuchi, Eiko

AU - Brock, Kenny V

AU - Burbelo, Peter D

AU - Rice, Charles M

AU - Lipkin, W Ian

PY - 2013/6

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N2 - The recent identification of nonprimate hepaciviruses in dogs and then in horses prompted us to look for pegiviruses (GB virus-like viruses) in these species. Although none were detected in canines, we found widespread natural infection of horses by a novel pegivirus. Unique genomic features and phylogenetic analyses confirmed that the tentatively named equine pegivirus (EPgV) represents a novel species within the Pegivirus genus. We also determined that EPgV causes persistent viremia whereas its clinical significance is undetermined.

AB - The recent identification of nonprimate hepaciviruses in dogs and then in horses prompted us to look for pegiviruses (GB virus-like viruses) in these species. Although none were detected in canines, we found widespread natural infection of horses by a novel pegivirus. Unique genomic features and phylogenetic analyses confirmed that the tentatively named equine pegivirus (EPgV) represents a novel species within the Pegivirus genus. We also determined that EPgV causes persistent viremia whereas its clinical significance is undetermined.

KW - Amino Acid Sequence

KW - Animals

KW - Base Sequence

KW - Flaviviridae

KW - Flaviviridae Infections

KW - Horse Diseases

KW - Horses

KW - Molecular Sequence Data

KW - Phylogeny

KW - Prevalence

KW - Sequence Analysis, DNA

KW - Species Specificity

KW - United States

KW - Viremia

U2 - 10.1128/JVI.00324-13

DO - 10.1128/JVI.00324-13

M3 - Journal article

C2 - 23596285

SN - 0022-538X

VL - 87

SP - 7185

EP - 7190

JO - Journal of Virology

JF - Journal of Virology

IS - 12

ER -

Identification of a pegivirus (GB virus-like virus) that infects horses

Abstract

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