Identification of a novel androgen receptor mutation in a family with multiple components compatible with the testicular dysgenesis syndrome

Grethe Lottrup, Anne Jørgensen, John E Nielsen, Niels Jørgensen, Morten Dunø, Anne Marie Vinggaard, Niels E Skakkebæk, Ewa Rajpert-De Meyts

30 Citationer (Scopus)

Abstract

Androgen signaling via the androgen receptor (AR) is essential for normal testis development and male reproductive functions. We describe a rare family with 3 males affected by a mild disorder of sex determination compatible with testicular dysgenesis syndrome (TDS), including subfertility, cryptorchidism, hypospadias, and testicular cancer, caused by a novel AR mutation.
OriginalsprogEngelsk
TidsskriftJournal of Clinical Endocrinology and Metabolism
Vol/bind98
Udgave nummer6
Sider (fra-til)2223-9
Antal sider7
ISSN0021-972X
DOI
StatusUdgivet - jun. 2013

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