Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

GH-replacement therapy in adults

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Aortic dimensions in girls and young women with Turner syndrome - a magnetic resonance imaging study

    Publikation: Bidrag til tidsskriftKonferenceartikelForskningpeer review

  2. Low birth weight and male reproductive function

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Metabolic aspects of insulin resistance in individuals born small for gestational age

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Pegvisomant treatment in a 4-year-old girl with neurofibromatosis type 1

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Characterisation and localisation of the endocannabinoid system components in the adult human testis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Populations, decreasing fertility, and reproductive health

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Why do normal children have acromegalic levels of IGF-I during puberty?

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Growth hormone (GH) deficiency in adults, whether GH deficient since childhood or patients rendered GH deficient in adult life, is associated with psychosocial maladjustment, reduced muscle strength and reduced exercise capacity. Body composition is significantly altered with increased fat and decreased muscle volume as compared to healthy subjects. Kidney function is subnormal, and so is sweat secretion. Epidemiological data suggest premature mortality due to cardiovascular disease in hypopituitary patients. Short-term GH treatment trials have shown improved psychosocial performance, normalization of body composition, increased muscle strength, improved exercise capacity, increased cardiac performance and increase in bone mineral mass as well as in serum markers of bone turnover, and normalization of kidney function. Thus GH replacement therapy in GH-deficient adults exhibits potential long-term beneficial effects. A number of important questions has to be addressed before long-term GH replacement therapy in GH-deficient adults can be considered on a routine basis.

OriginalsprogEngelsk
TidsskriftHormone Research
Vol/bind36 Suppl 1
Sider (fra-til)66-72
Antal sider7
ISSN0301-0163
StatusUdgivet - 1991

ID: 44937201