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International Working Group consensus response evaluation criteria in lymphoma (RECIL 2017)

Publikation: Bidrag til tidsskriftReviewForskningpeer review


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  • A Younes
  • P Hilden
  • B Coiffier
  • A Hagenbeek
  • G Salles
  • W Wilson
  • J F Seymour
  • K Kelly
  • J Gribben
  • M Pfreunschuh
  • F Morschhauser
  • H Schoder
  • A D Zelenetz
  • J Rademaker
  • R Advani
  • N Valente
  • C Fortpied
  • T E Witzig
  • L H Sehn
  • A Engert
  • R I Fisher
  • P-L Zinzani
  • M Federico
  • M Hutchings
  • C Bollard
  • M Trneny
  • Y A Elsayed
  • K Tobinai
  • J S Abramson
  • N Fowler
  • A Goy
  • M Smith
  • S Ansell
  • J Kuruvilla
  • M Dreyling
  • C Thieblemont
  • R F Little
  • I Aurer
  • M H J Van Oers
  • K Takeshita
  • A Gopal
  • S Rule
  • S de Vos
  • I Kloos
  • M S Kaminski
  • M Meignan
  • L H Schwartz
  • J P Leonard
  • S J Schuster
  • V E Seshan
Vis graf over relationer

In recent years, the number of approved and investigational agents that can be safely administered for the treatment of lymphoma patients for a prolonged period of time has substantially increased. Many of these novel agents are evaluated in early-phase clinical trials in patients with a wide range of malignancies, including solid tumors and lymphoma. Furthermore, with the advances in genome sequencing, new "basket" clinical trial designs have emerged that select patients based on the presence of specific genetic alterations across different types of solid tumors and lymphoma. The standard response criteria currently in use for lymphoma are the Lugano Criteria which are based on [18F]2-fluoro-2-deoxy-D-glucose positron emission tomography or bidimensional tumor measurements on computerized tomography scans. These differ from the RECIST criteria used in solid tumors, which use unidimensional measurements. The RECIL group hypothesized that single-dimension measurement could be used to assess response to therapy in lymphoma patients, producing results similar to the standard criteria. We tested this hypothesis by analyzing 47 828 imaging measurements from 2983 individual adult and pediatric lymphoma patients enrolled on 10 multicenter clinical trials and developed new lymphoma response criteria (RECIL 2017). We demonstrate that assessment of tumor burden in lymphoma clinical trials can use the sum of longest diameters of a maximum of three target lesions. Furthermore, we introduced a new provisional category of a minor response. We also clarified response assessment in patients receiving novel immune therapy and targeted agents that generate unique imaging situations.

TidsskriftAnnals of Oncology
Udgave nummer7
Sider (fra-til)1436-1447
Antal sider12
StatusUdgivet - 1 jul. 2017

ID: 52764973