- Hospitaler/Afdelinger Se de enkelte afdelingers forskningsprofil
- Forskere Søg forskere og deres videnskabelige arbejde
- Publikationer Publikationer med forskere fra Region Hovedstaden
- Forskningsprojekter Søg projekter/clinical trials i Region Hovedstaden
- Aktiviteter Med forskere fra Region Hovedstaden
Forskning
Udskriv
Switch language
Region Hovedstaden
- en del af Københavns Universitetshospital
Udgivet
Hypoxia-inducible factors--regulation, role and comparative aspects in tumourigenesis
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Harvard
Hansen, AE, Kristensen, AT, Law, I, Jørgensen, J & Engelholm, SA 2011, 'Hypoxia-inducible factors--regulation, role and comparative aspects in tumourigenesis' Veterinary and Comparative Oncology, bind 9, nr. 1, s. 16-37. https://doi.org/10.1111/j.1476-5829.2010.00233.x
APA
Hansen, A. E., Kristensen, A. T., Law, I., Jørgensen, J., & Engelholm, S. A. (2011). Hypoxia-inducible factors--regulation, role and comparative aspects in tumourigenesis. Veterinary and Comparative Oncology, 9(1), 16-37. https://doi.org/10.1111/j.1476-5829.2010.00233.x
CBE
Hansen AE, Kristensen AT, Law I, Jørgensen J, Engelholm SA. 2011. Hypoxia-inducible factors--regulation, role and comparative aspects in tumourigenesis. Veterinary and Comparative Oncology. 9(1):16-37. https://doi.org/10.1111/j.1476-5829.2010.00233.x
MLA
Hansen, A E o.a.. "Hypoxia-inducible factors--regulation, role and comparative aspects in tumourigenesis". Veterinary and Comparative Oncology. 2011, 9(1). 16-37. https://doi.org/10.1111/j.1476-5829.2010.00233.x
Vancouver
Hansen AE, Kristensen AT, Law I, Jørgensen J, Engelholm SA. Hypoxia-inducible factors--regulation, role and comparative aspects in tumourigenesis. Veterinary and Comparative Oncology. 2011;9(1):16-37. https://doi.org/10.1111/j.1476-5829.2010.00233.x
Author
Bibtex
@article{ea80ca261e4a4035810c004706c456cc,
title = "Hypoxia-inducible factors--regulation, role and comparative aspects in tumourigenesis",
abstract = "Hypoxia-inducible factors (HIFs) play a key role in the cellular response experienced in hypoxic tumours, mediating adaptive responses that allow hypoxic cells to survive in the hostile environment. Identification and understanding of tumour hypoxia and the influence on cellular processes carries important prognostic information and may help identify potential hypoxia circumventing and targeting strategies. This review summarizes current knowledge on HIF regulation and function in tumour cells and discusses the aspects of using companion animals as comparative spontaneous cancer models. Spontaneous tumours in companion animals hold a great research potential for the evaluation and understanding of tumour hypoxia and in the development of hypoxia-targeting therapeutics.",
keywords = "Animals, Basic Helix-Loop-Helix Transcription Factors, Cat Diseases, Cats, Cell Hypoxia, Disease Models, Animal, Dog Diseases, Dogs, Hypoxia-Inducible Factor 1, MicroRNAs, Neoplasms, Neoplastic Stem Cells",
author = "Hansen, {A E} and Kristensen, {A T} and I Law and Jan J{\o}rgensen and Engelholm, {S A}",
note = "{\circledC} 2010 Blackwell Publishing Ltd.",
year = "2011",
doi = "10.1111/j.1476-5829.2010.00233.x",
language = "English",
volume = "9",
pages = "16--37",
journal = "Veterinary and Comparative Oncology",
issn = "1476-5810",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "1",
}
RIS
TY - JOUR
T1 - Hypoxia-inducible factors--regulation, role and comparative aspects in tumourigenesis
AU - Hansen, A E
AU - Kristensen, A T
AU - Law, I
AU - Jørgensen, Jan
AU - Engelholm, S A
N1 - © 2010 Blackwell Publishing Ltd.
PY - 2011
Y1 - 2011
N2 - Hypoxia-inducible factors (HIFs) play a key role in the cellular response experienced in hypoxic tumours, mediating adaptive responses that allow hypoxic cells to survive in the hostile environment. Identification and understanding of tumour hypoxia and the influence on cellular processes carries important prognostic information and may help identify potential hypoxia circumventing and targeting strategies. This review summarizes current knowledge on HIF regulation and function in tumour cells and discusses the aspects of using companion animals as comparative spontaneous cancer models. Spontaneous tumours in companion animals hold a great research potential for the evaluation and understanding of tumour hypoxia and in the development of hypoxia-targeting therapeutics.
AB - Hypoxia-inducible factors (HIFs) play a key role in the cellular response experienced in hypoxic tumours, mediating adaptive responses that allow hypoxic cells to survive in the hostile environment. Identification and understanding of tumour hypoxia and the influence on cellular processes carries important prognostic information and may help identify potential hypoxia circumventing and targeting strategies. This review summarizes current knowledge on HIF regulation and function in tumour cells and discusses the aspects of using companion animals as comparative spontaneous cancer models. Spontaneous tumours in companion animals hold a great research potential for the evaluation and understanding of tumour hypoxia and in the development of hypoxia-targeting therapeutics.
KW - Animals
KW - Basic Helix-Loop-Helix Transcription Factors
KW - Cat Diseases
KW - Cats
KW - Cell Hypoxia
KW - Disease Models, Animal
KW - Dog Diseases
KW - Dogs
KW - Hypoxia-Inducible Factor 1
KW - MicroRNAs
KW - Neoplasms
KW - Neoplastic Stem Cells
U2 - 10.1111/j.1476-5829.2010.00233.x
DO - 10.1111/j.1476-5829.2010.00233.x
M3 - Journal article
VL - 9
SP - 16
EP - 37
JO - Veterinary and Comparative Oncology
JF - Veterinary and Comparative Oncology
SN - 1476-5810
IS - 1
ER -
ID: 33272943