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Hypoxia briefly increases diuresis but reduces plasma volume by fluid redistribution in women

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Harvard

Roche, J, Rasmussen, P, Gatterer, H, Roveri, G, Turner, R, van Hall, G, Maillard, M, Walzl, A, Kob, M, Strapazzon, G, Goetze, JP, Schäfer, ST, Kammerer, T, Nader, E, Connes, P, Robert, M, Mueller, T, Feraille, E & Siebenmann, C 2022, 'Hypoxia briefly increases diuresis but reduces plasma volume by fluid redistribution in women', American Journal of Physiology: Heart and Circulatory Physiology, bind 323, nr. 6, s. H1068-H1079. https://doi.org/10.1152/ajpheart.00394.2022

APA

Roche, J., Rasmussen, P., Gatterer, H., Roveri, G., Turner, R., van Hall, G., Maillard, M., Walzl, A., Kob, M., Strapazzon, G., Goetze, J. P., Schäfer, S. T., Kammerer, T., Nader, E., Connes, P., Robert, M., Mueller, T., Feraille, E., & Siebenmann, C. (2022). Hypoxia briefly increases diuresis but reduces plasma volume by fluid redistribution in women. American Journal of Physiology: Heart and Circulatory Physiology, 323(6), H1068-H1079. https://doi.org/10.1152/ajpheart.00394.2022

CBE

Roche J, Rasmussen P, Gatterer H, Roveri G, Turner R, van Hall G, Maillard M, Walzl A, Kob M, Strapazzon G, Goetze JP, Schäfer ST, Kammerer T, Nader E, Connes P, Robert M, Mueller T, Feraille E, Siebenmann C. 2022. Hypoxia briefly increases diuresis but reduces plasma volume by fluid redistribution in women. American Journal of Physiology: Heart and Circulatory Physiology. 323(6):H1068-H1079. https://doi.org/10.1152/ajpheart.00394.2022

MLA

Vancouver

Author

Roche, Johanna ; Rasmussen, Peter ; Gatterer, Hannes ; Roveri, Giulia ; Turner, Rachel ; van Hall, Gerrit ; Maillard, Marc ; Walzl, Anna ; Kob, Michael ; Strapazzon, Giacomo ; Goetze, Jens Peter ; Schäfer, Simon Thomas ; Kammerer, Tobias ; Nader, Elie ; Connes, Philippe ; Robert, Mélanie ; Mueller, Thomas ; Feraille, Eric ; Siebenmann, Christoph. / Hypoxia briefly increases diuresis but reduces plasma volume by fluid redistribution in women. I: American Journal of Physiology: Heart and Circulatory Physiology. 2022 ; Bind 323, Nr. 6. s. H1068-H1079.

Bibtex

@article{82b86af405794f839ea66cfe04f1aef3,
title = "Hypoxia briefly increases diuresis but reduces plasma volume by fluid redistribution in women",
abstract = "We have recently reported that hypobaric hypoxia (HH) reduces plasma volume (PV) in men by decreasing total circulating plasma protein (TCPP). Here, we investigated whether this applies to women and whether an inflammatory response and/or endothelial glycocalyx shedding could facilitate the TCCP reduction. We further investigated whether acute HH induces a short-lived diuretic response that was overlooked in our recent study, where only 24-h urine volumes were evaluated. In a strictly controlled crossover protocol, 12 women underwent two 4-day sojourns in a hypobaric chamber: one in normoxia (NX) and one in HH equivalent to 3,500-m altitude. PV, urine output, TCPP, and markers for inflammation and glycocalyx shedding were repeatedly measured. Total body water (TBW) was determined pre- and postsojourns by deuterium dilution. PV was reduced after 12 h of HH and thereafter remained 230-330 mL lower than in NX (P < 0.0001). Urine flow was 45% higher in HH than in NX throughout the first 6 h (P = 0.01) but lower during the second half of the first day (P < 0.001). Twenty-four-hour urine volumes (P ≥ 0.37) and TBW (P ≥ 0.14) were not different between the sojourns. TCPP was lower in HH than in NX at the same time points as PV (P < 0.001), but inflammatory or glycocalyx shedding markers were not consistently increased. As in men, and despite initially increased diuresis, HH-induced PV contraction in women is driven by a loss of TCPP and ensuing fluid redistribution, rather than by fluid loss. The mechanism underlying the TCPP reduction remains unclear but does not seem to involve inflammation or glycocalyx shedding.NEW & NOTEWORTHY This study is the first to investigate the mechanisms underlying plasma volume (PV) contraction in response to hypoxia in women while strictly controlling for confounders. PV contraction in women has a similar time course and magnitude as in men and is driven by the same mechanism, namely, oncotically driven redistribution rather than loss of fluid. We further report that hypoxia facilitates an increase in diuresis, that is, however, short-lived and of little relevance for PV regulation.",
keywords = "Male, Humans, Female, Plasma Volume/physiology, Hypoxia, Altitude, Diuresis, Inflammation",
author = "Johanna Roche and Peter Rasmussen and Hannes Gatterer and Giulia Roveri and Rachel Turner and {van Hall}, Gerrit and Marc Maillard and Anna Walzl and Michael Kob and Giacomo Strapazzon and Goetze, {Jens Peter} and Sch{\"a}fer, {Simon Thomas} and Tobias Kammerer and Elie Nader and Philippe Connes and M{\'e}lanie Robert and Thomas Mueller and Eric Feraille and Christoph Siebenmann",
year = "2022",
month = dec,
day = "1",
doi = "10.1152/ajpheart.00394.2022",
language = "English",
volume = "323",
pages = "H1068--H1079",
journal = "American Journal of Physiology: Heart and Circulatory Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "6",

}

RIS

TY - JOUR

T1 - Hypoxia briefly increases diuresis but reduces plasma volume by fluid redistribution in women

AU - Roche, Johanna

AU - Rasmussen, Peter

AU - Gatterer, Hannes

AU - Roveri, Giulia

AU - Turner, Rachel

AU - van Hall, Gerrit

AU - Maillard, Marc

AU - Walzl, Anna

AU - Kob, Michael

AU - Strapazzon, Giacomo

AU - Goetze, Jens Peter

AU - Schäfer, Simon Thomas

AU - Kammerer, Tobias

AU - Nader, Elie

AU - Connes, Philippe

AU - Robert, Mélanie

AU - Mueller, Thomas

AU - Feraille, Eric

AU - Siebenmann, Christoph

PY - 2022/12/1

Y1 - 2022/12/1

N2 - We have recently reported that hypobaric hypoxia (HH) reduces plasma volume (PV) in men by decreasing total circulating plasma protein (TCPP). Here, we investigated whether this applies to women and whether an inflammatory response and/or endothelial glycocalyx shedding could facilitate the TCCP reduction. We further investigated whether acute HH induces a short-lived diuretic response that was overlooked in our recent study, where only 24-h urine volumes were evaluated. In a strictly controlled crossover protocol, 12 women underwent two 4-day sojourns in a hypobaric chamber: one in normoxia (NX) and one in HH equivalent to 3,500-m altitude. PV, urine output, TCPP, and markers for inflammation and glycocalyx shedding were repeatedly measured. Total body water (TBW) was determined pre- and postsojourns by deuterium dilution. PV was reduced after 12 h of HH and thereafter remained 230-330 mL lower than in NX (P < 0.0001). Urine flow was 45% higher in HH than in NX throughout the first 6 h (P = 0.01) but lower during the second half of the first day (P < 0.001). Twenty-four-hour urine volumes (P ≥ 0.37) and TBW (P ≥ 0.14) were not different between the sojourns. TCPP was lower in HH than in NX at the same time points as PV (P < 0.001), but inflammatory or glycocalyx shedding markers were not consistently increased. As in men, and despite initially increased diuresis, HH-induced PV contraction in women is driven by a loss of TCPP and ensuing fluid redistribution, rather than by fluid loss. The mechanism underlying the TCPP reduction remains unclear but does not seem to involve inflammation or glycocalyx shedding.NEW & NOTEWORTHY This study is the first to investigate the mechanisms underlying plasma volume (PV) contraction in response to hypoxia in women while strictly controlling for confounders. PV contraction in women has a similar time course and magnitude as in men and is driven by the same mechanism, namely, oncotically driven redistribution rather than loss of fluid. We further report that hypoxia facilitates an increase in diuresis, that is, however, short-lived and of little relevance for PV regulation.

AB - We have recently reported that hypobaric hypoxia (HH) reduces plasma volume (PV) in men by decreasing total circulating plasma protein (TCPP). Here, we investigated whether this applies to women and whether an inflammatory response and/or endothelial glycocalyx shedding could facilitate the TCCP reduction. We further investigated whether acute HH induces a short-lived diuretic response that was overlooked in our recent study, where only 24-h urine volumes were evaluated. In a strictly controlled crossover protocol, 12 women underwent two 4-day sojourns in a hypobaric chamber: one in normoxia (NX) and one in HH equivalent to 3,500-m altitude. PV, urine output, TCPP, and markers for inflammation and glycocalyx shedding were repeatedly measured. Total body water (TBW) was determined pre- and postsojourns by deuterium dilution. PV was reduced after 12 h of HH and thereafter remained 230-330 mL lower than in NX (P < 0.0001). Urine flow was 45% higher in HH than in NX throughout the first 6 h (P = 0.01) but lower during the second half of the first day (P < 0.001). Twenty-four-hour urine volumes (P ≥ 0.37) and TBW (P ≥ 0.14) were not different between the sojourns. TCPP was lower in HH than in NX at the same time points as PV (P < 0.001), but inflammatory or glycocalyx shedding markers were not consistently increased. As in men, and despite initially increased diuresis, HH-induced PV contraction in women is driven by a loss of TCPP and ensuing fluid redistribution, rather than by fluid loss. The mechanism underlying the TCPP reduction remains unclear but does not seem to involve inflammation or glycocalyx shedding.NEW & NOTEWORTHY This study is the first to investigate the mechanisms underlying plasma volume (PV) contraction in response to hypoxia in women while strictly controlling for confounders. PV contraction in women has a similar time course and magnitude as in men and is driven by the same mechanism, namely, oncotically driven redistribution rather than loss of fluid. We further report that hypoxia facilitates an increase in diuresis, that is, however, short-lived and of little relevance for PV regulation.

KW - Male

KW - Humans

KW - Female

KW - Plasma Volume/physiology

KW - Hypoxia

KW - Altitude

KW - Diuresis

KW - Inflammation

U2 - 10.1152/ajpheart.00394.2022

DO - 10.1152/ajpheart.00394.2022

M3 - Journal article

C2 - 36269645

VL - 323

SP - H1068-H1079

JO - American Journal of Physiology: Heart and Circulatory Physiology

JF - American Journal of Physiology: Heart and Circulatory Physiology

SN - 0363-6135

IS - 6

ER -

ID: 85882100