Hypoxia and exercise provoke both lactate release and lactate oxidation by the human brain

Morten Overgaard, Peter Rasmussen, Aske M Bohm, Thomas Seifert, Patrice Brassard, Morten Zaar, Pernille Halberg Homann, Kevin A Evans, Henning M Bay Nielsen, Niels H Secher

    66 Citationer (Scopus)

    Abstract

    Lactate is shuttled between organs, as demonstrated in the Cori cycle. Although the brain releases lactate at rest, during physical exercise there is a cerebral uptake of lactate. Here, we evaluated the cerebral lactate uptake and release in hypoxia, during exercise and when the two interventions were combined. We measured cerebral lactate turnover via a tracer dilution method ([1-(13)C]lactate), using arterial to right internal jugular venous differences in 9 healthy individuals (5 males and 4 females), at rest and during 30 min of submaximal exercise in normoxia and hypoxia (F(i)o(2) 10%, arterial oxygen saturation 72±10%, mean±SD). Whole-body lactate turnover increased 3.5-fold and 9-fold at two workloads in normoxia and 18-fold during exercise in hypoxia. Although middle cerebral artery mean flow velocity increased during exercise in hypoxia, calculated cerebral mitochondrial oxygen tension decreased by 13 mmHg (P
    OriginalsprogEngelsk
    TidsskriftF A S E B Journal
    Sider (fra-til)3012-20
    ISSN0892-6638
    DOI
    StatusUdgivet - 2012

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