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Hypotension associated with MTS is aggravated by early activation of TEA during open esophagectomy

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@article{147203f564484f64aba02077879594ca,
title = "Hypotension associated with MTS is aggravated by early activation of TEA during open esophagectomy",
abstract = "Objective: A mesenteric traction syndrome (MTS) is elicited by prostacyclin (PGI 2)induced vasodilation and identified by facial flushing, tachycardia, and hypotension during abdominal surgery. We evaluated whether thoracic epidural anesthesia (TEA) influences the incidence of MTS. Design: Randomized, blinded controlled trial. Setting: Single-center university hospital. Participants: Fifty patients undergoing open esophagectomy. Interventions: Patients were randomized to either early (EA, after induction of general anesthesia) or late activation of TEA (LA, after re-established gastric continuity). Plasma 6-keto-PGF 1α, a stable metabolite of PGI 2 and interleukine-6 (IL6) were measured in plasma during surgery along with hemodynamic variables and MTS graded according to facial flushing together with plasma C-reactive protein on the third post-operative day. Results: Forty-five patients met the inclusion criteria. Development of MTS tended to be more prevalent with EA (n=13/25 [52%]) than with LA TEA (n=5/20 [25%], p=0.08). For patients who developed MTS, there was a transient increase in plasma 6-keto-PGF 1α by 15 min of surgery and plasma IL6 (p<0.001) as C-reactive protein (P<0.009) increased. EA TEA influenced the amount of phenylephrine needed to maintain mean arterial pressure >60 mmHg in patients who developed MTS (0.16 [0.016–0.019] mg/min vs MTS and LA TEA 0.000 [0.000–0.005] mg/min, p<0.001). Conclusion: The incidence of MTS is not prevented by TEA in patients undergoing open esophagectomy. On the contrary, the risk of hypotension is increased in patients exposed to TEA during surgery, and the results suggest that it is advantageous to delay activation of TEA. Also, MTS seems to be associated with a systemic inflammatory response, maybe explaining the aggravated post-operative outcome. ",
keywords = "Epidural anesthesia, Esophagectomy, Mesenteric traction syndrome",
author = "Strandby, {Rune B} and Rikard Ambrus and Ring, {Linea L} and Nikolaj Nerup and Secher, {Niels H} and Goetze, {Jens P} and Achiam, {Michael P} and Svendsen, {Lars B}",
note = "{\textcopyright} 2021 Strandby et al.",
year = "2021",
doi = "10.2147/LRA.S294556",
language = "English",
volume = "14",
pages = "33--42",
journal = "Local and Regional Anesthesia",
issn = "1178-7112",
publisher = "Dove Medical Press Ltd",

}

RIS

TY - JOUR

T1 - Hypotension associated with MTS is aggravated by early activation of TEA during open esophagectomy

AU - Strandby, Rune B

AU - Ambrus, Rikard

AU - Ring, Linea L

AU - Nerup, Nikolaj

AU - Secher, Niels H

AU - Goetze, Jens P

AU - Achiam, Michael P

AU - Svendsen, Lars B

N1 - © 2021 Strandby et al.

PY - 2021

Y1 - 2021

N2 - Objective: A mesenteric traction syndrome (MTS) is elicited by prostacyclin (PGI 2)induced vasodilation and identified by facial flushing, tachycardia, and hypotension during abdominal surgery. We evaluated whether thoracic epidural anesthesia (TEA) influences the incidence of MTS. Design: Randomized, blinded controlled trial. Setting: Single-center university hospital. Participants: Fifty patients undergoing open esophagectomy. Interventions: Patients were randomized to either early (EA, after induction of general anesthesia) or late activation of TEA (LA, after re-established gastric continuity). Plasma 6-keto-PGF 1α, a stable metabolite of PGI 2 and interleukine-6 (IL6) were measured in plasma during surgery along with hemodynamic variables and MTS graded according to facial flushing together with plasma C-reactive protein on the third post-operative day. Results: Forty-five patients met the inclusion criteria. Development of MTS tended to be more prevalent with EA (n=13/25 [52%]) than with LA TEA (n=5/20 [25%], p=0.08). For patients who developed MTS, there was a transient increase in plasma 6-keto-PGF 1α by 15 min of surgery and plasma IL6 (p<0.001) as C-reactive protein (P<0.009) increased. EA TEA influenced the amount of phenylephrine needed to maintain mean arterial pressure >60 mmHg in patients who developed MTS (0.16 [0.016–0.019] mg/min vs MTS and LA TEA 0.000 [0.000–0.005] mg/min, p<0.001). Conclusion: The incidence of MTS is not prevented by TEA in patients undergoing open esophagectomy. On the contrary, the risk of hypotension is increased in patients exposed to TEA during surgery, and the results suggest that it is advantageous to delay activation of TEA. Also, MTS seems to be associated with a systemic inflammatory response, maybe explaining the aggravated post-operative outcome.

AB - Objective: A mesenteric traction syndrome (MTS) is elicited by prostacyclin (PGI 2)induced vasodilation and identified by facial flushing, tachycardia, and hypotension during abdominal surgery. We evaluated whether thoracic epidural anesthesia (TEA) influences the incidence of MTS. Design: Randomized, blinded controlled trial. Setting: Single-center university hospital. Participants: Fifty patients undergoing open esophagectomy. Interventions: Patients were randomized to either early (EA, after induction of general anesthesia) or late activation of TEA (LA, after re-established gastric continuity). Plasma 6-keto-PGF 1α, a stable metabolite of PGI 2 and interleukine-6 (IL6) were measured in plasma during surgery along with hemodynamic variables and MTS graded according to facial flushing together with plasma C-reactive protein on the third post-operative day. Results: Forty-five patients met the inclusion criteria. Development of MTS tended to be more prevalent with EA (n=13/25 [52%]) than with LA TEA (n=5/20 [25%], p=0.08). For patients who developed MTS, there was a transient increase in plasma 6-keto-PGF 1α by 15 min of surgery and plasma IL6 (p<0.001) as C-reactive protein (P<0.009) increased. EA TEA influenced the amount of phenylephrine needed to maintain mean arterial pressure >60 mmHg in patients who developed MTS (0.16 [0.016–0.019] mg/min vs MTS and LA TEA 0.000 [0.000–0.005] mg/min, p<0.001). Conclusion: The incidence of MTS is not prevented by TEA in patients undergoing open esophagectomy. On the contrary, the risk of hypotension is increased in patients exposed to TEA during surgery, and the results suggest that it is advantageous to delay activation of TEA. Also, MTS seems to be associated with a systemic inflammatory response, maybe explaining the aggravated post-operative outcome.

KW - Epidural anesthesia

KW - Esophagectomy

KW - Mesenteric traction syndrome

UR - http://www.scopus.com/inward/record.url?scp=85102466481&partnerID=8YFLogxK

U2 - 10.2147/LRA.S294556

DO - 10.2147/LRA.S294556

M3 - Journal article

C2 - 33688249

VL - 14

SP - 33

EP - 42

JO - Local and Regional Anesthesia

JF - Local and Regional Anesthesia

SN - 1178-7112

ER -

ID: 64127771