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Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography

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@article{c4a54621b8894a2f9c0215822f2f1d0f,
title = "Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography",
abstract = "BACKGROUND: Recent GWAS studies have identified more than 300 SNPs associated with variation in blood pressure. We investigated whether a genetic risk score constructed from these variants is associated with burden of coronary heart disease.METHODS: From 2010-2014, 4,809 individuals admitted to coronary angiography in Capital Region of Copenhagen were genotyped. We calculated hypertension GRS comprised of GWAS identified SNPs associated with blood pressure. We performed logistic regression analyses to estimate the risk of hypertension and prevalent CHD. We also assessed the severity of CHD associated with the GRS. The analyses were performed using GRS quartiles. We used the Inter99 cohort to validate our results and to investigate for possible pleiotropy for the GRS with other CHD risk factors.RESULTS: In COGEN, adjusted odds ratios comparing the 2nd, 3rd and 4th cumulative GRS quartiles with the reference were 1.12(95{\%} CI 0.95-1.33), 1.35(95{\%} CI 1.14-1.59) and 1.29(95{\%} CI 1.09-1.53) respectively, for prevalent CHD. The adjusted multinomial logistic regression showed that 3rd and 4th GRS quartiles were associated with increased odds of developing two(OR 1.33, 95{\%} CI 1.04-1.71 and OR 1.36, 95{\%} CI 1.06-1.75, respectively) and three coronary vessel disease(OR 1.77, 95{\%} CI 1.36-2.30 and OR 1.65, 95{\%} CI 1.26-2.15, respectively). Similar results for incident CHD were observed in the Inter99 cohort. The hypertension GRS did not associate with type 2 diabetes, smoking, BMI or hyperlipidemia.CONCLUSION: Hypertension GRS quartiles were associated with an increased risk of hypertension, prevalent CHD, and burden of coronary vessel disease in a dose-response pattern. We showed no evidence for pleiotropy with other risk factors for CHD.",
author = "{Luk{\'a}cs Krogager}, Maria and Skals, {Regitze Kuhr} and Appel, {Emil Vincent R} and Schnurr, {Theresia M} and Line Engelbrechtsen and Have, {Christian Theil} and Oluf Pedersen and Thomas Engstr{\o}m and Roden, {Dan M} and Gunnar Gislason and Poulsen, {Henrik Enghusen} and Lars K{\o}ber and Steen Stender and Torben Hansen and Niels Grarup and Charlotte Andersson and Christian Torp-Pedersen and Peter Weeke",
year = "2018",
month = "12",
day = "19",
doi = "10.1371/journal.pone.0208645",
language = "English",
volume = "13",
pages = "e0208645",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "12",

}

RIS

TY - JOUR

T1 - Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography

AU - Lukács Krogager, Maria

AU - Skals, Regitze Kuhr

AU - Appel, Emil Vincent R

AU - Schnurr, Theresia M

AU - Engelbrechtsen, Line

AU - Have, Christian Theil

AU - Pedersen, Oluf

AU - Engstrøm, Thomas

AU - Roden, Dan M

AU - Gislason, Gunnar

AU - Poulsen, Henrik Enghusen

AU - Køber, Lars

AU - Stender, Steen

AU - Hansen, Torben

AU - Grarup, Niels

AU - Andersson, Charlotte

AU - Torp-Pedersen, Christian

AU - Weeke, Peter

PY - 2018/12/19

Y1 - 2018/12/19

N2 - BACKGROUND: Recent GWAS studies have identified more than 300 SNPs associated with variation in blood pressure. We investigated whether a genetic risk score constructed from these variants is associated with burden of coronary heart disease.METHODS: From 2010-2014, 4,809 individuals admitted to coronary angiography in Capital Region of Copenhagen were genotyped. We calculated hypertension GRS comprised of GWAS identified SNPs associated with blood pressure. We performed logistic regression analyses to estimate the risk of hypertension and prevalent CHD. We also assessed the severity of CHD associated with the GRS. The analyses were performed using GRS quartiles. We used the Inter99 cohort to validate our results and to investigate for possible pleiotropy for the GRS with other CHD risk factors.RESULTS: In COGEN, adjusted odds ratios comparing the 2nd, 3rd and 4th cumulative GRS quartiles with the reference were 1.12(95% CI 0.95-1.33), 1.35(95% CI 1.14-1.59) and 1.29(95% CI 1.09-1.53) respectively, for prevalent CHD. The adjusted multinomial logistic regression showed that 3rd and 4th GRS quartiles were associated with increased odds of developing two(OR 1.33, 95% CI 1.04-1.71 and OR 1.36, 95% CI 1.06-1.75, respectively) and three coronary vessel disease(OR 1.77, 95% CI 1.36-2.30 and OR 1.65, 95% CI 1.26-2.15, respectively). Similar results for incident CHD were observed in the Inter99 cohort. The hypertension GRS did not associate with type 2 diabetes, smoking, BMI or hyperlipidemia.CONCLUSION: Hypertension GRS quartiles were associated with an increased risk of hypertension, prevalent CHD, and burden of coronary vessel disease in a dose-response pattern. We showed no evidence for pleiotropy with other risk factors for CHD.

AB - BACKGROUND: Recent GWAS studies have identified more than 300 SNPs associated with variation in blood pressure. We investigated whether a genetic risk score constructed from these variants is associated with burden of coronary heart disease.METHODS: From 2010-2014, 4,809 individuals admitted to coronary angiography in Capital Region of Copenhagen were genotyped. We calculated hypertension GRS comprised of GWAS identified SNPs associated with blood pressure. We performed logistic regression analyses to estimate the risk of hypertension and prevalent CHD. We also assessed the severity of CHD associated with the GRS. The analyses were performed using GRS quartiles. We used the Inter99 cohort to validate our results and to investigate for possible pleiotropy for the GRS with other CHD risk factors.RESULTS: In COGEN, adjusted odds ratios comparing the 2nd, 3rd and 4th cumulative GRS quartiles with the reference were 1.12(95% CI 0.95-1.33), 1.35(95% CI 1.14-1.59) and 1.29(95% CI 1.09-1.53) respectively, for prevalent CHD. The adjusted multinomial logistic regression showed that 3rd and 4th GRS quartiles were associated with increased odds of developing two(OR 1.33, 95% CI 1.04-1.71 and OR 1.36, 95% CI 1.06-1.75, respectively) and three coronary vessel disease(OR 1.77, 95% CI 1.36-2.30 and OR 1.65, 95% CI 1.26-2.15, respectively). Similar results for incident CHD were observed in the Inter99 cohort. The hypertension GRS did not associate with type 2 diabetes, smoking, BMI or hyperlipidemia.CONCLUSION: Hypertension GRS quartiles were associated with an increased risk of hypertension, prevalent CHD, and burden of coronary vessel disease in a dose-response pattern. We showed no evidence for pleiotropy with other risk factors for CHD.

U2 - 10.1371/journal.pone.0208645

DO - 10.1371/journal.pone.0208645

M3 - Journal article

VL - 13

SP - e0208645

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 12

ER -

ID: 56113989