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Region Hovedstaden - en del af Københavns Universitetshospital

Hypertension and liver disease.

Publikation: Bidrag til tidsskriftReview

  1. Dietary sodium: where science and policy conflict: impact of the 2013 IOM Report on Sodium Intake in Populations

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Remission and regression of diabetic nephropathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Pathophysiology Behind Cardiopulmonary Complications of Cirrhosis and Portal Hypertension

    Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

  2. Statins for cirrhosis: almost ready for clinical application

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

Vis graf over relationer
Arterial hypertension is a common disorder with a frequency of 10% to 15% in subjects in the 40- to 60-year age group. Yet most reports find the prevalence of arterial hypertension in patients with chronic liver disease (cirrhosis) much lower. In this review, we consider the alterations in systemic hemodynamics in cirrhosis. The most characteristic findings in cirrhotic patients are vasodilatation with low systemic vascular resistance, increased cardiac output, high arterial compliance, secondary activation of counterregulatory systems (sympathetic nervous system, renin-angiotensin-aldosterone system, neuropituitary release of vasopressin), and resistance to vasopressors. The vasodilatory state is mediated through nitric oxide, calcitonin gene-related peptide, adrenomedullin, and other vasodilators, and is most pronounced in the splanchnic area. This constitutes an effective (although relative) counterbalance to increased arterial blood pressure. Subjects with established arterial hypertension (essential, secondary) may become normotensive during the development of cirrhosis, and arterial hypertension is rarely manifested in patients with cirrhosis, even in cases with renovascular disease and high circulating renin activity. There is much dispute as to the understanding of homeostatic regulation in cirrhotic patients with manifest arterial hypertension. This is a topic for future research.
Bidragets oversatte titelHypertension and liver disease.
TidsskriftCurrent Hypertension Reports
Udgave nummer6
Sider (fra-til)453-461
Antal sider9
StatusUdgivet - 2004

ID: 32504540