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Hyperpolarized singlet NMR on a small animal imaging system

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Laustsen, Christoffer ; Pileio, Giuseppe ; Tayler, Michael C D ; Brown, Lynda J ; Brown, Richard C D ; Levitt, Malcolm H ; Ardenkjaer-Larsen, Jan Henrik. / Hyperpolarized singlet NMR on a small animal imaging system. I: Magnetic Resonance in Medicine. 2012 ; Bind 68, Nr. 4. s. 1262-5.

Bibtex

@article{455d6a5fcb7543b189e650cdbacfb6e6,
title = "Hyperpolarized singlet NMR on a small animal imaging system",
abstract = "Nuclear spin hyperpolarization makes a significant advance toward overcoming the sensitivity limitations of in vivo magnetic resonance imaging, particularly in the case of low-gamma nuclei. The sensitivity may be improved further by storing the hyperpolarization in slowly relaxing singlet populations of spin-1/2 pairs. Here, we report hyperpolarized (13) C spin order transferred into and retrieved from singlet spin order using a small animal magnetic resonance imaging scanner. For spins in sites with very similar chemical shifts, singlet spin order is sustained in high magnetic field without requiring strong radiofrequency irradiation. The demonstration of robust singlet-to-magnetization conversion, and vice versa, on a small animal scanner, is promising for future in vivo and clinical deployments. Magn Reson Med, 2012. {\circledC} 2012 Wiley Periodicals, Inc.",
author = "Christoffer Laustsen and Giuseppe Pileio and Tayler, {Michael C D} and Brown, {Lynda J} and Brown, {Richard C D} and Levitt, {Malcolm H} and Ardenkjaer-Larsen, {Jan Henrik}",
note = "Copyright {\circledC} 2012 Wiley Periodicals, Inc.",
year = "2012",
month = "10",
doi = "10.1002/mrm.24430",
language = "English",
volume = "68",
pages = "1262--5",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John/Wiley & Sons, Inc. John/Wiley & Sons Ltd",
number = "4",

}

RIS

TY - JOUR

T1 - Hyperpolarized singlet NMR on a small animal imaging system

AU - Laustsen, Christoffer

AU - Pileio, Giuseppe

AU - Tayler, Michael C D

AU - Brown, Lynda J

AU - Brown, Richard C D

AU - Levitt, Malcolm H

AU - Ardenkjaer-Larsen, Jan Henrik

N1 - Copyright © 2012 Wiley Periodicals, Inc.

PY - 2012/10

Y1 - 2012/10

N2 - Nuclear spin hyperpolarization makes a significant advance toward overcoming the sensitivity limitations of in vivo magnetic resonance imaging, particularly in the case of low-gamma nuclei. The sensitivity may be improved further by storing the hyperpolarization in slowly relaxing singlet populations of spin-1/2 pairs. Here, we report hyperpolarized (13) C spin order transferred into and retrieved from singlet spin order using a small animal magnetic resonance imaging scanner. For spins in sites with very similar chemical shifts, singlet spin order is sustained in high magnetic field without requiring strong radiofrequency irradiation. The demonstration of robust singlet-to-magnetization conversion, and vice versa, on a small animal scanner, is promising for future in vivo and clinical deployments. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc.

AB - Nuclear spin hyperpolarization makes a significant advance toward overcoming the sensitivity limitations of in vivo magnetic resonance imaging, particularly in the case of low-gamma nuclei. The sensitivity may be improved further by storing the hyperpolarization in slowly relaxing singlet populations of spin-1/2 pairs. Here, we report hyperpolarized (13) C spin order transferred into and retrieved from singlet spin order using a small animal magnetic resonance imaging scanner. For spins in sites with very similar chemical shifts, singlet spin order is sustained in high magnetic field without requiring strong radiofrequency irradiation. The demonstration of robust singlet-to-magnetization conversion, and vice versa, on a small animal scanner, is promising for future in vivo and clinical deployments. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc.

U2 - 10.1002/mrm.24430

DO - 10.1002/mrm.24430

M3 - Journal article

VL - 68

SP - 1262

EP - 1265

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 4

ER -

ID: 36423908