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Hyperpolarized singlet NMR on a small animal imaging system

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DOI

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Vis graf over relationer
Nuclear spin hyperpolarization makes a significant advance toward overcoming the sensitivity limitations of in vivo magnetic resonance imaging, particularly in the case of low-gamma nuclei. The sensitivity may be improved further by storing the hyperpolarization in slowly relaxing singlet populations of spin-1/2 pairs. Here, we report hyperpolarized 13C spin order transferred into and retrieved from singlet spin order using a small animal magnetic resonance imaging scanner. For spins in sites with very similar chemical shifts, singlet spin order is sustained in high magnetic field without requiring strong radiofrequency irradiation. The demonstration of robust singlet-to-magnetization conversion, and vice versa, on a small animal scanner, is promising for future in vivo and clinical deployments.
OriginalsprogEngelsk
TidsskriftMagnetic Resonance in Medicine
Vol/bind68
Udgave nummer4
Sider (fra-til)1262-5
Antal sider4
ISSN0740-3194
DOI
StatusUdgivet - okt. 2012

ID: 36423908