@article{4c6c000b6c9245428aed5302579e0378,
title = "Hyperpolarised 3-He MRI vs HRCT in COPD and normal volunteers - PHIL trial",
abstract = "To apply hyperpolarized (HP) (3)He MRI to identify patients with chronic obstructive lung disease (COPD) from healthy volunteers and compare HP (3)He MRI findings with CT in a multicentre study. Quantitative measurements of HP (3)He MRI (apparent diffusion coefficient=ADC) and CT (mean lung density=MLD) were correlated with pulmonary function tests.A prospective three centre study enrolled 122 subjects with COPD (either acquired or genetic) and age matched never smokers. All diagnostic studies were completed in 94 subjects (52 with COPD; 13 with alpha-1-antitrypsin deficiency (A1AD); 29 healthy subjects; 63 men, 31 women; median age 62 years). The consensus assessment of radiologists blinded for other test results estimated non-ventilated lung volume (HP (3)He MRI) and percentage diseased lung (CT). Quantitative evaluation of all data for each center consisted of ADC (HP (3)He MRI) and MLD measurements (CT), and correlation with FEV1/FVC indicating airway obstruction, and CO diffusion capacity (DLCO) indicating alveolar destruction.Using lung function tests as reference, regional analysis of HP (3)He MRI and CT correctly categorized normal volunteers in 100 and 97 %, COPD in 42% and 69% and A1AT in 69% and 85% of the cases, respectively. Direct comparison of HP (3)He MRI and CT revealed 23% of subjects with moderate/severe structural abnormalities had only mild ventilation defects. In comparison with lung function tests, ADC was more effective in separating COPD patients from healthy subjects than MLD (p<0.001 vs. 0.038). ADC measurements showed better correlation with DLCO than MLD (r=0.59 vs. 0.29).Hyperpolarized (3)He MRI correctly categorizes patients with COPD and volunteers. It offers additional functional information, without the use of ionizing radiation whereas HRCT gives better morphological information. We showed the feasibility of a multcentre study using different MR systems.",
author = "{van Beek}, {E J R} and Dahmen, {A M} and T Stavngaard and Gast, {K K} and Heussel, {C P} and F Krummenauer and J Schmiedeskamp and Wild, {J M} and S{\o}gaard, {L V} and Morbach, {A E} and Schreiber, {L M} and H-U Kauczor",
year = "2009",
doi = "10.1183/09031936.00138508",
language = "English",
volume = "34",
pages = "1311--21",
journal = "The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology",
issn = "1399-3003",
publisher = "European Respiratory Society",
number = "6",
}