Hydrocephalus Study Design: Testing New Hypotheses in Clinical Studies and Bench-to-Bedside Research

Marianne Juhler; Torben Skovbo Hansen; Hans V G Novrup; Nanna MacAulay; Tina Nørgaard Munch

doi:10.1016/j.wneu.2021.12.100

Hydrocephalus Study Design: Testing New Hypotheses in Clinical Studies and Bench-to-Bedside Research

Marianne Juhler
, Torben Skovbo Hansen
, Hans V G Novrup
, Nanna MacAulay
, Tina Nørgaard Munch

Afdeling for Hjerne- og Nervekirurgi NEU

Abstract

In this article, we aimed to describe some of the currently most challenging problems in neurosurgical management of hydrocephalus and how these can be reasons for inspiration for and development of research. We chose 4 areas of focus: 2 dedicated to improvement of current treatments (shunt implant surgery and endoscopic hydrocephalus surgery) and 2 dedicated to emerging future treatment principles (molecular mechanisms of cerebrospinal fluid secretion and hydrocephalus genetics).

Originalsprog	Engelsk
Tidsskrift	World Neurosurgery
Vol/bind	161
Sider (fra-til)	424-431
Antal sider	8
ISSN	1878-8750
DOI	https://doi.org/10.1016/j.wneu.2021.12.100
Status	Udgivet - maj 2022

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abstract = "In this article, we aimed to describe some of the currently most challenging problems in neurosurgical management of hydrocephalus and how these can be reasons for inspiration for and development of research. We chose 4 areas of focus: 2 dedicated to improvement of current treatments (shunt implant surgery and endoscopic hydrocephalus surgery) and 2 dedicated to emerging future treatment principles (molecular mechanisms of cerebrospinal fluid secretion and hydrocephalus genetics).",

keywords = "ETV, Genetics, Hydrocephalus, Molecular mechanisms, Shunt, Translational research",

author = "Marianne Juhler and Hansen, \{Torben Skovbo\} and Novrup, \{Hans V G\} and Nanna MacAulay and Munch, \{Tina N{\o}rgaard\}",

year = "2022",

month = may,

doi = "10.1016/j.wneu.2021.12.100",

language = "English",

volume = "161",

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journal = "World Neurosurgery",

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T2 - Testing New Hypotheses in Clinical Studies and Bench-to-Bedside Research

AU - Juhler, Marianne

AU - Hansen, Torben Skovbo

AU - Novrup, Hans V G

AU - MacAulay, Nanna

AU - Munch, Tina Nørgaard

PY - 2022/5

Y1 - 2022/5

N2 - In this article, we aimed to describe some of the currently most challenging problems in neurosurgical management of hydrocephalus and how these can be reasons for inspiration for and development of research. We chose 4 areas of focus: 2 dedicated to improvement of current treatments (shunt implant surgery and endoscopic hydrocephalus surgery) and 2 dedicated to emerging future treatment principles (molecular mechanisms of cerebrospinal fluid secretion and hydrocephalus genetics).

AB - In this article, we aimed to describe some of the currently most challenging problems in neurosurgical management of hydrocephalus and how these can be reasons for inspiration for and development of research. We chose 4 areas of focus: 2 dedicated to improvement of current treatments (shunt implant surgery and endoscopic hydrocephalus surgery) and 2 dedicated to emerging future treatment principles (molecular mechanisms of cerebrospinal fluid secretion and hydrocephalus genetics).

KW - ETV

KW - Genetics

KW - Hydrocephalus

KW - Molecular mechanisms

KW - Shunt

KW - Translational research

UR - https://www.scopus.com/pages/publications/85129355352

U2 - 10.1016/j.wneu.2021.12.100

DO - 10.1016/j.wneu.2021.12.100

M3 - Journal article

C2 - 35505563

SN - 1878-8750

VL - 161

SP - 424

EP - 431

JO - World Neurosurgery

JF - World Neurosurgery

ER -

Hydrocephalus Study Design: Testing New Hypotheses in Clinical Studies and Bench-to-Bedside Research

Abstract

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