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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients

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  • Jean Farup
  • Jesper Just
  • Frank de Paoli
  • Lin Lin
  • Jonas Brorson Jensen
  • Tine Billeskov
  • Ines Sanchez Roman
  • Cagla Cömert
  • Andreas Buch Møller
  • Luca Madaro
  • Elena Groppa
  • Rikard Göran Fred
  • Ulla Kampmann
  • Lars C Gormsen
  • Steen B Pedersen
  • Peter Bross
  • Tinna Stevnsner
  • Nikolaj Eldrup
  • Tune H Pers
  • Fabio M V Rossi
  • Pier Lorenzo Puri
  • Niels Jessen
Vis graf over relationer

Type 2 diabetes mellitus (T2DM) is associated with impaired skeletal muscle function and degeneration of the skeletal muscles. However, the mechanisms underlying the degeneration are not well described in human skeletal muscle. Here we show that skeletal muscle of T2DM patients exhibit degenerative remodeling of the extracellular matrix that is associated with a selective increase of a subpopulation of fibro-adipogenic progenitors (FAPs) marked by expression of THY1 (CD90)-the FAPCD90+. We identify platelet-derived growth factor (PDGF) as a key FAP regulator, as it promotes proliferation and collagen production at the expense of adipogenesis. FAPsCD90+ display a PDGF-mimetic phenotype, with high proliferative activity, clonogenicity, and production of extracellular matrix. FAPCD90+ proliferation was reduced by in vitro treatment with metformin. Furthermore, metformin treatment reduced FAP content in T2DM patients. These data identify a PDGF-driven conversion of a subpopulation of FAPs as a key event in the fibrosis development in T2DM muscle.

OriginalsprogEngelsk
TidsskriftCell Metabolism
Vol/bind33
Udgave nummer11
Sider (fra-til)2201-2214.e11
ISSN1550-4131
DOI
StatusUdgivet - 2 nov. 2021

Bibliografisk note

Copyright © 2021 Elsevier Inc. All rights reserved.

ID: 74849213